Neurodegenerative non-human transgenic mammal expressing...

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C800S003000, C800S009000, C536S023100

Reexamination Certificate

active

07342146

ABSTRACT:
The present invention provides a neurodegenerative, non-human transgenic mammal whose cells contain a TrkA-hFc transgene for encoding at least a TrkA fusion protein and the use thereof.

REFERENCES:
Schonheit et al., 2004, Neurobiology of Aging, 25: 697-711.
Franz et al., 1997, J. Mol. Med., 75: 115-129.
Racay, 2002, Bratisl Lek Listy, 103: 121-126.
Rita Levi-Montalcini et al., “Effects of Mouse Tumor Transplantation on the Nervous System” Western Journals, Annals of the New York Academy of Sciences, vol. 55, Art 3, 1952, pp. 330-334.
Satoshi Morimoto et al., “Elevated Blood Pressure in Transgenic Mice With Brain-Specific Expression of Human Angiotensinogen Driven by the Glial Fibrillary Acidic Protein Promoter” Circulation Research Journal of the American Heart Association, Aug. 17, 2001, pp. 365-372.
Giorgio Palu et al., “Gene Therapy of Brain and Endocrine Tumors” Croatian Medical Journal, vol. 42, No. 4, 2001, pp. 473-477.
Jose Segovia et al., “Differentiation-dependent expression of transgenes in engineered astrocyte cell lines” Neuroscience Letter, vol. 242, 1998, pp. 172-176.
Ningya Shi et al., “Brain-specific expression of an exogenous gene after l.v. administration” PNAS, vol. 98, No. 22, Oct. 23, 2001, pp. 12754-12759.
Absalom Zamorano et al., “Transcriptionally Mediated Gene Targeting of gas1 to Glioma Cells Elicits Growth Arrest and Apoptosis” Journal of neuroscience Research, vol. 72, 2003, pp. 256-263.
Eric J. Huang et al., “Neurotrophins: Roles in Neuronal Development and Function” Annual Review of Neuroscience; 2001, vol. 24 ProQuest science Journals, pp. 677-736.
Ardem Patapoutian et al., “Trk receptors: mediators of neurotrophin action” Current Opinion in Neurobiology 2001, vol. 11, pp. 272-280.
Elliott J. Mufson et al., “Reduction in P140-TrkA Receptor Protein within the Nucleus Basalis and Cortex in Alzheimer Disease” Experimental Neurology 146, 1997, pp. 91-103.
Esperanza Arias, et al., “Unequal Neuroprotection Afforded by the Acetylcholinesterase Inhibitors Galantamine, Donepezil, and Rivastigmine in SH-SY5Y Neuroblastoma Cells: Role of Nicotinic Receptors” The Journal of Pharmaology and Experimental Therapeutics 2005, vol. 315, No. 3, pp. 1346-1353.
Christopher Janus et al., “Transgenic mouse models of Alzheimer's disease” Physiology & Behavior 2001, vol. 73, pp. 873-886.
Jonathan D. Cooper et al., “Failed retrograde transport of NGF in a mouse model of Down's Syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF Infusion” PNAS, Aug. 28, 2001, vol. 98, No. 18, pp. 10439-10444.
Brian J. Hock et al., “Transgenic mouse models of Alzheimer's Disease” TRENDS in Genetics, vol. 17, No. 10, Oct. 2001, pp. S7-S12.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Neurodegenerative non-human transgenic mammal expressing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neurodegenerative non-human transgenic mammal expressing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neurodegenerative non-human transgenic mammal expressing... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2805555

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.