Neuroblastoma-associated regulator gene

Details Neuroblastoma-associated regulator gene Neuroblastoma-associated regulator gene

1995-06-06

1997-11-04

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 71, 435 72, 435 79, 536 243, 536 2433, 536 231, 5303882, 530350, C12Q 168, C12P 1934, G01N 3353, C07H 2102

Patent

active

056838786

ABSTRACT:
Disclosed is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 which codes for a helix-loop-helix protein with the designation HEIR-1. The loss of this gene is significantly correlated with allelic tumor deletions in neuroblastomas and expression of this correlates inversely both N-myc overexpression in tumors and with N-myc expression in normal development. The cDNA and antibodies coding for HEIR-1 are used for the diagnosis of pathological conditions associated with aberration in the region of the neuroblastoma consensus deletion.

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