Neuroactive peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530300, 530328, 530326, A61K 3800

Patent

active

061072710

ABSTRACT:
Compositions and methods are described for the specific identification of NMDA receptors, and for the specific identification and manipulation of NMDA glycine co-agonist biological activity.

REFERENCES:
Thompson L.T. et al., (1992), "Hippocampus-dependent learning facilitated by a monoclonal antibody of D-cyloserine", Nature, vol. 359, Oct. 15, 1992, pp. 638-641.
Bekenstein et al., (1990), "Autoradiographic evidence that NMDA receptor-coupled channels are located postsynaptically and not presynaptically in the preforant path-denate granule cell system of the rat hippocampal formation" Brain Research, 514(2):334-342.
Hoffman., (1991), "NMDA receptor cloned-Twice?", Science, 254:801-802.
Kozikowski et al., (1990), "Synthesis and bioactivity of a new class of rigid glutamate anaalogues." Journal of Medicinal Chemistry, 33:1561-1571.
Bliss and Collingridge, (1993), "A synaptic model of memory: long-term potentiation n the hippocampus" Nature, 361:31-39.
Moskal and Schaffner, (1986). "Monoclonal antibodies to the dendrate gyrus: immunocytochemical characterization and flow cytometric analysis of hippocampal neurons bearing a unique cell-surface antigen" The Journal of Neuroscience, 6(7):2045-2053.
Stanton, Sarvey and Moskal, (1987), "Inhibition of the production and maintenance of long-term potentiation in rat hippocampal slices by a monoclonal antibody" Proceedings of the National Academy of Science, (USA), 84(6):1684-1688.
Leonard and Kelso. (1990). "Apparent desensitazation of NMDA responses in Xenopus Oocytes involves calcium-dependent chloride current" Neuron, 4:53-60.
Kelso et al., (1992), "Protein Kinase C-mediated enhancement of NMDA currents by metabotropic glutamate receptors in xenopus oocytes" J. Physiology, 449: 705-718.
Morris, (1984), "Developments of a water-maze procedure for studying spatial learning in the rat" J. Neurosci. Math., 11:47-60.
Brandeis et al., (1989), "The use of the Morris water maze in the study of memory and learning" Int. J. Neurosci., 48:29-69.
Opello et al. (1993). "AF64A impairs acquisition and performance of a spatial, but not a cued water maze task: relation to cholinergic hypofunction" Physiol. Behav., 54(6):1227-1233.
Disterhoft et al., (1977), "Nictitating membrane conditioning to tone in the immobilized albino rabbit" Brain Res., 137: 127-143.
Thomson et al., (1994), "A System for quanititative analysis of associative learning. Part 1. Hardware interfaces with cross-species applications" J. Neurosci. Meth., 54: 109-117.
Moyer et al., (1990), "Hippocampectomy disrupts trace eye-blink conditioning in rabbits" Behav. Neurosci., 104(2): 243-252.
Akase et al., (1994), "A system for quantitative analysis of associative learing" J. Neurosci. Method., 54: 119-130.
Weiss and Thompson, (1992), "Delayed acquisition of eyeblink conditioning in aged F1 hybrid (Fischer-344 x brown Norway) rat" Neurobiol. Aging, 13: 319-323.
Tonkiss and Rawlins, (1991), The competitive NMDA antagonist AP5, but not the non-competitive antagonist MK801, induces delay-related impairment in spatial working memory in rats Exp. Brain Res., 85: 349-358.
Skelton, (1988). "Bilateral cerebellar lesions disrupt conditioned cyclid responses in unrestrained rats" Behav. Neurosci., 102(4): 586-590.
Haring et al., (1991), "Glycine-like modulation of N-methyl-D-aspartate receptors by a monoclonal antibody that enhances long-term potentiation" J. Neurochem., 1-10.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Neuroactive peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neuroactive peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neuroactive peptides will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-581180

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.