Neuregulin response element and uses therefor

Details Neuregulin response element and uses therefor Neuregulin response element and uses therefor

1998-06-05

2000-12-19

Guzo, David

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

536 241, 536 231, 4353201, 435348, 435349, 435352, 435363, 435368, 435371, C12N 1585, C12N 1563, C07H 2104

Patent

active

061626414

ABSTRACT:
Methods for therapeutics and for screens are provided using a 15 bp sequence in the rat .epsilon.-subunit promoter that regulates PTPase, neuregulin and Ras-dependent gene expression. As this 15 bp sequence is necessary also for low .epsilon.-subunit gene expression in extrajunctional regions of the muscle fiber, the screens can identify agents that simultaneously and oppositely modulate expression in .epsilon.-subunit expression of synaptic and extrajunctional regions.

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