Neural transplantation using pluripotent neuroepithelial cells

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

07048921

ABSTRACT:
The subject invention pertains to a novel method of correction of behavioral and/or psychological deficits made possible by the intracerebral transplantation of pluripotent neuroepithelial cells. Cells, cell lines, pharmaceutical preparations, medicaments, methods for the production and maintenance of the cell lines for use in the method of the invention are encompassed by the invention.

REFERENCES:
patent: 5270191 (1993-12-01), McKay et al.
patent: 5580777 (1996-12-01), Bernard et al.
patent: 5690927 (1997-11-01), Major et al.
patent: 5753491 (1998-05-01), Major et al.
patent: 5817773 (1998-10-01), Wilson et al.
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 6197585 (2001-03-01), Stringer
patent: 6200806 (2001-03-01), Thomson
patent: 6399384 (2002-06-01), Jat
patent: 6528306 (2003-03-01), Snyder et al.
patent: 6569421 (2003-05-01), Hodges
patent: 2002/0123143 (2002-09-01), Toma et al.
patent: 2003/0147873 (2003-08-01), Sinden et al.
patent: WO 97/10329 (1997-03-01), None
patent: WO 89/09816 (1989-10-01), None
patent: WO 92/11355 (1992-07-01), None
patent: WO 93/18137 (1993-09-01), None
patent: WO 98/07841 (1998-02-01), None
patent: WO 00/50568 (2000-08-01), None
Netto et al. Foetal grafts from hippocampal regio superior alleviate ischaemie-induced behavioral deficits** pp. 107-112 1993.
Sinden et al. Recovery of spatial learning by grafts of a conditionally jimmortalized hippocampal neuroepithelial cell line into the ischaemia-lesioned hippocampus pp. 599-608 vol. 91 No. 3 1997.
Sanberg et al. Cellular therapeutic approaches for neurodegenrative disorders pp. 139-142 2998.
Sicheffler et al. Marrow-mindedness: a perspective on neuropoiesis 1999 22, pp. 348-357.
Hodges et al. Cognitive deficits induced by global cerebral ischaemia: Prospects for transplant therapy pp. 763-780 1997.
Rashid-Doubell et al. Effects of basic fibroblast growth factor and gamma interferon on hippocampal progenitor cells derived from the H-2Kb-tsA58 transgenic mouse p. S63 (no date).
Renfranz et al., 1991, Cell, vol. 66, p. 713-729.
White et al., 1992, J. Chem. Neuroanatomy, vol. 5, p. 327-330.
Villa, 2000, Exp. Neurol., vol. 161, p. 67-84.
Gray, Aug. 29, 1999, Philosophical Transactions of the Royal Soc. London, vol. 354, No. 1388. p. 1407-1421.
Snyder, Evan Y., David L. Deitcher, Christopher Walsh, Susan Arnold-Aldea, Erika A. Hartwieg, Constance L. Cepko (Jan. 10, 1992) “Multipotent Neural Cell Lines Can Engraft and Participate in Development of Mouse Cerebellum”Cell68:33-51.
Snyder, Evan Y. and John H. Wolfe (1996) “Central nervous system cell transplantation: a novel therapy for storage diseases?”Curr. Opin. Neurol.9:126-136.
Snyder, Evan Y., Cliff Yoon, Jonathan D. Flax, Jeffrey D. Macklis (Oct. 14, 1997) “Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex”Proc. Natl. Acad. Sci.94(21):11663-11668.
Virley, David, Rosalind M. Ridley, John D. Sinden et al. (1999) “Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field”Brain122(2321-2335.
Whittemore, S. R. et al. “Isolation and characterization of conditionally immortalized astrocyte cell lines derived from adult human spinal cord”Glia, Mar. 1994, 10:221-226.
Anderson, W.F. “Human gene therapy”Nature, 1998, 392:25-30.
Allay, J.A. et al. “LacZ and interleukin-3 expressionin vivoafter retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors”Human Gene Therapy, 1997, 8:1417-1427.
Chopp, M. et al. “Adult bone marrow transplantation for treatment of stroke in adult mice”Society for Neuroscience, 1999, 25:1309, abstract No. 528.2 (abstract).
Cepko, C.L. “Immortalization of neural cells via retrovirus-mediated oncogene transduction”Ann. Rev. Neurosci.,1989, 12:47-65.
Frederiksen, K. et al. “Immortalization of Precursor Cells from the Mammalian CNS”Neuron, 1988, 1:439-448.
Jat, P.S. “Direct derivation of conditionally immortal cell lines from anH-2Kb-tsA58 transgenic mouse”Proc. Natl. Acad. Sci. USA, 1991, 88:5096-5100.
Major, E.O. et al. “Establishment of a line of human fetal glial cells that supports JC virus multiplication”Proc. Natl. Acad. Sci. USA, 1985, 82:1257-1261.
Mezey, E. and K.J. Chandross “Bone marrow: a possible alternative source of cells in the adult nervous system”Euro. J. Pharmacology, 2000, 405:297-302.
Palu, G. et al. “In pursuit of new developments for gene therapy of human diseases”J. Biotechnology, 1999, 68:1-13.
Wyllie, F.S. et al. “A phenotypically and karyotypically stable human thyroid epithelial line conditionally immortalized by SV40 large T antigen”Cancer Res.,1992, 52:2938-2945.
Stem Cells: Scientific Progress and Future Research Directions, Jun. 2001, Introductory Chapter and Chapters 8 and 11.

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