Neural thread protein gene expression and detection of alzheimer

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352523, 4352528, 4353201, 536 231, 536 235, C12N 1500

Patent

active

059486341

ABSTRACT:
The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes coding for the neuronal thread proteins. This invention is also directed to substantially pure neural thread protein, immunodiagnostic and molecular diagnostic methods to detect the presence of neural thread proteins, and the use of nucleic acid sequences which code for neural thread proteins in gene therapy.

REFERENCES:
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4666829 (1987-05-01), Glenner et al.
patent: 4735210 (1988-04-01), Goldenberg
patent: 4816388 (1989-03-01), Sipe et al.
patent: 4866042 (1989-09-01), Neuwelt
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 5168053 (1992-12-01), Altman et al.
patent: 5436169 (1995-07-01), Iovanna et al.
patent: 5501979 (1996-03-01), Geller et al.
Studier et al., 185 Meth. Enz. 60-89 (David V. Goeddel, ed. 1990).
Tsuji et al., 11 EMBO J. 4843-50 (1992).
Gutierrez et al., "Gene therapy for cancer," The Lancet 339:715-721 (1992).
Benowitz, L.I. and Lewis, E.R., "Increased Transport of 44,000- to 49,000-Dalton Acidic Proteins During Regeneration of the Goldfish Optic Nerve: A Two-Dimensional Gel Analysis," J. Neurosci. 3(11):2153-2163 (1983).
de la Monte, S.M. and Wands, J.R. "Neuronal thread protein over-expression in brains with Alzheimer's disease lesions," J. Neurol. Sci. 113:152-164 (1992).
de la Monte et al., "Enhanced Expression of an Exocrine Pancreatic Protein in Alzheimer's Disease and the Developing Human Brain," J. Clin. Invest. 86:1004-1013 (1990).
de la Monte et al., "Increased Levels of Neuronal Thread Protein in Cerebrospinal Fluid of Patients with Alzheimer's Disease," Ann. Neurol. 32:733-742 (1992).
De Caro et al., "Characterization of a Protein Isolated From Pancreatic Calculi of Men Suffering From Chronic Calcifying Pancreatitis," Biochem. Biophys. Res. Comm. 87(4):1176-1182 (1979).
De Caro et al., "Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice," Eur. J. Biochem. 168:201-207 (1987).
De Caro et al., "The molecular characteristics of a human pnacreatic acidic phosphoprotein that inhibits calcium carbonate crystal growth," Biochem. J. 222:669-677 (1984).
De Graan et al., "Phosphoprotein B-50 in Nerve Growth Cones from Fetal Rat Brain," Neurosci. Lett. 61:235-241 (1985).
DePamphilis, M.L., "Origins of DNA Replication in Matazoan Chromosomes," J. Biol. Chem. 268(1):1-4 (1993).
European Search Report for European Patent Publication No. 0 378 924 (Nov. 6, 1991).
Forstner et al., "Selective Precipitation of 14 kDa Stone/Thread Proteins by Concentration of Pancreaticobiliary Secretions: Relevance to Pancreatic Ductal Obstruction, Pancreatic Failure, and CF," J. Pediatric Gastroenterology and Nutrition 8:313-320 (1989).
Gross et al., "Isolation, Characterization, and Distribution of an Unusual Pancreatic Human Secretory Protein," J. Clin. Invest. 76:2115-2126 (1985).
Gross et al., "An unusual bovine pancreatic protein exhibiting pH-dependent globule-fibril transformation and unique amino acid sequence," PNAS USA 82:5627-5631 (1985).
Guy-Crotte et al., "Characterization and N-Terminal Sequence of a Degradation Product of 14,000 Molecular Weight Isolated from Human Pancreatic Juice," Biochem. Biophys. Res. Comm. 125(2):516-523 (1984).
Ishii et al., "Presence of Neurofilament Protein in Alzheimer's Neurofibrillary Tangles (ANT), An Immunofluorescent Study," Acta Neuropathol. (Berl.) 48:105-112 (1979).
Kalil, K. and Skene, J.H.P., "Elevated Synthesis of an Axonally Transported Protein Correlates with Axon Outgrowth in Normal and Injured Pyramidal Tracts," J. Neurosci. 6(9):2563-2570 (1986).
Lasserre et al., "A Novel Gene (HIP) Activated in Human Primary Liver Cancer," Cancer Res. 52:5089-5095 (1992).
Lathe, R., "Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data, Theoretical and Practical Considerations," J. Molec. Biol. 183:1-12 (1985).
Ozturk et al., "Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain," PNAS USA 86:419-423 (1989).
Perry et al., "Alteration of the Neurofilament-Microtubule Network in Alzheimer Disease and Other Neurogenerative Disorders," in: Alterations of the Neuronal Cytoskeleton in Alzheimer's Disease, Plenum Press, pp. 137-149 (1987).
Sano et al., "Immuno-PCR: Very Sensitive Antigen Detection by Means of Specific Antibody-DNA Conjugates," Science 258:120-122 (1992).
Sano et al., "A Streptavidin-Protein A Chimera That Allows One-Step Production of a Variety of Specific Antibody Conjugates," Bio/Technology 9:1378-1381 (1991).
Selkoe, D.J., "Altered Structural Proteins in Plaques and Tangles: What Do They Tell Us About the Biology of Alzheimer's Disease?" Neurobiology of Aging 7:425-432 (1986).
Terazono et al., "A Novel Gene Activated in Regenerating Islets," J. Biol. Chem. 263(5):2111-2114 (1988).
Watanabe et al., "Complete Nucleotide Sequence of Human reg Gene and Its Expression in Normal and Tumoral Tissues," J. Biol. Chem. 265(13):7432-7439 (1990).
Wischik et al., "Structural Characterization of the Core of the Paired Helical Filament of Alzheimer Disease," PNAS USA 85:4884-4888 (1988).
Wolozin et al., "A Neuronal Antigen in the Brains of Alzheimer Patients," Science 232:648-650 (1986).
Abe, M., et al., "Production and Immunodiagnostic Applications of Antihuman Light Chain Monoclonal Antibodies," Am. J. Clin. Pathol. 100:67-74 (Jul. 1993).
Bahmanyar, S., et al., "Localization of Amyloid .beta. Protein Messenger RNA in Brains from Pathents with Alzheimer's Disease," Science 237:77-80 (Jul. 3, 1987).
Denman, R.B., et al., "Ribozyme Mediated Degradation of .beta.-amyloid Peptide Precursor mRNA in COS-7 Cells," Nucl. Acids Res. 22(12):2375-2382 (Jun. 25, 1994).
Ponte, P., et al., "A New A4 Amyloid mRNA Contains a Domain Homologous to Serine Proteinase Inhibitors," Nature 331:525-527 (Feb. 11, 1988).
A copy of the International Search Report for the corresponding PCT application, International Application No. PCT/US95/17111. (Mar. 25, 1996).
Chong, J. et al., "Detention and Measurement of Neural Thread Protein (NTP) in Cerebrospinal Fluid (CSF): A Potential Antemortem Marker for Alzheimer's Disease," Soc. Neurosci. 17--Abstracts from the 21st Annual Meeting:1259, Abstract No. 498.7 (1991).
Chong, J.K. et al., "Automated Microparticle Enzyme Immunoassay for Neural Thread Protein in Cerebrospinal Fluid from Alzheimer's Disease Patients," J. Clin. Lab. Anal. 6:379-383 (1992).
Ghanbari, H. et al., "Detection and Measurement of Alzheimer's Disease Associated Protein (ADAP) in Cerebrospinal Fluid (CSF): An Antemortem Marker for Alzheimer's Disease," Soc. Neurosci. 17--Abstracts from the 21st Annual Meeting:1259, Abstract No. 498.8 (1991).
Abraham, C.R. et al., "Immunochemical Identification of the Serine Protease Inhibitor .alpha..sub.1 -Antichymotrypsin in the Brain Amyloid Deposits of Alzheimer's Disease," Cell 52:487-501 (Feb. 1988).
de la Monte, S.M. and J.R. Wands, "Neuronal Thread Protein: A Potential Marker for Alzheimer's Disease," J. Neuropathol. Exp. Neurol. 50:316, Abstract No. 83 (May 1991).
de la Monte, S.M. and J.R. Wands, "Elevated Neuronal Thread Protein Levels in Ventricular Fluid and Temporal Cortex of Alzheimer's Disease," Neurobiol Aging 13. Suppl. 1:S26, Abstract No. 103 (1992).
Figarella, C. et al., "Pancreatic Stone Protein, Protein X, and Thread Protein,"Lancet 1(8526):222-223 (Jan. 1987).
Glenner, G.G. et al., "Alzheimer's Disease: Initial Report of the Purification and Characterization of a Novel Cerebrovascular Amyloid Protein," Biochem. Biophys. Res. Comm. 120(3):885-890 (May 1984).
Goldgaber, D. et al., "Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease," Science 235:877-880 (Feb. 1987).
Joachim, C.L. et al., "Amyloid .beta.-protein deposition in tissues other than brain in

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Neural thread protein gene expression and detection of alzheimer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neural thread protein gene expression and detection of alzheimer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neural thread protein gene expression and detection of alzheimer will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1803750

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.