Neural stem cells and use thereof for brain tumor therapy

Details Neural stem cells and use thereof for brain tumor therapy Neural stem cells and use thereof for brain tumor therapy

2007-03-06

2007-03-06

Nguyen, Quang (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C435S455000, C435S320100

Reexamination Certificate

active

09795675

ABSTRACT:
The present invention is based upon a surprising finding that stem cells, more particularly neural stem cells, can migrate throughout a brain tumor and track metastatic brain tumor cells. The invention provides a method for treating brain tumors by administering genetically engineered neural stem cells in an individual affected by brain tumors. The invention also provides a method of preparing genetically engineered neural stem cells and a composition comprising genetically engineered neural stem cells in a pharmaceutically acceptable carrier.

REFERENCES:
patent: 5624830 (1997-04-01), Mullen et al.
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753506 (1998-05-01), Johe
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5935852 (1999-08-01), Follettie et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 6156306 (2000-12-01), Brownlee et al.
Lacorazza et al (1996) Nature Medicine 2:424-429.
Fox, Yahoo! News, Jan. 14, 2003 (Accessed Jan. 14, 2003 from http:/
ews.yahoo.com
ews?tmpl=story2&cid=570&u=
m/20030114/sc—nm/health—genetherapy—dc&printer=1).
Fox, ASM News, Feb. 2000, 66 (2): 1-3.
Verma et al (1997) Nature 389:239-242.
Palù et al (1999) J. Biotechnol. 68:1-13.
Noble (2000) Nature Medicine 6:369-370.
Park et al (2002) Gene Therapy 9:613-624.
Noble, M. Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage? PNAS 97:12393-12395, 2000.
Aboody et al. Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas, PNAS 97:12846-12851, 2000.
Dang et al. Gene therapy and translational cancer research. Clin. Cancer Res. 5:471-474, 1999.
Romano et al. Latest developments in gene transfer technology: Achievements, perspectives, and controversies over therapeutic applications. Stem Cells 18:19-39, 2000.
Snyder, E., et al.,Nature(London) 374:367-370, 1995.
Weiss, S., et al.,Trends Nuerosci. 19:387-393, 1996.
McKay, R.,Science276:66-71, 1997.
Snyder, E., et al.,Proc. Natl. Acad. Sci. USA94:11663-11668, 1997.
Flax, J.D., et al.,Nat. Biotech. 16:1033-1039, 1998.
Topf, N., et al.,Gene Ther. 5:507-513, 1998.
Cage,e t al.Am. Rev. Neurosci. 18:159-192, 1995.
Whittemore, et al.,Molecular Neurobiology12:13-39, 1996.
Snyder,The Neuroscientist4:408-425, 1998.
Snyder, et al.,Cell68:33-51, 1992.
Renfranz, et al.,Cell66:713-729, 1991.
Snyder, et al.,Current Opin. In Pediatrics8:558-568, 1996.
Park,J. Neurotrauma16:675-687, 1999.
Aboody-Guterman, et al.,Neuro Report8:3801-3808, 1997.

Affiliated with

Also associated with

Rating

Neural stem cells and use thereof for brain tumor therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neural stem cells and use thereof for brain tumor therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neural stem cells and use thereof for brain tumor therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3783792