Neural cell adhesion protein nerve prosthesis

Surgery – Instruments – Surgical mesh – connector – clip – clamp or band

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606155, 623 12, 623 66, 424423, 435 1, 514 2, 530839, A61F 202

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049558927

ABSTRACT:
The neural cell adhesion molecule is used in nerve prostheses for the repair of peripheral nerve damage in mammals, both animal and man. In particular, in a process wherein a crushed or severed nerve ending is entubulated by use of a prosthetic device, a neural cell adhesion protein is added to the prosthetic device to increase the rate of growth of the fibrous components of the nerve, to more rapidly regenerate the nerve, and provide a more complete restitution of the function of the muscle served by the regenerated nerve.

REFERENCES:
patent: 4662884 (1987-05-01), Stensaas
Seilheimer et al.; "Studies of Adhesion Molecules Mediating Interactions Between Cells of Peripheral Nervous System Indicate a Major Role for L1 in Mediating Sensory Neuron Growth on Schwann Cells in Culture", J. Cell Biol. 107(1) 1988, 341-352.
Joanne K. Daniloff, Giovanni Levi, Martin Grumet, Francois Rieger and Gerald M. Edelman, Altered Expression of Neuronal Cell Adhesion Molecules Induced by Nerve Injury and Repair, The Journal of Cell Biology, vol. 103, 9/86, pp. 929-945.
Gerald M. Edelman, Cell-Adhesion Molecules: A Molecular Basis for Animal Form, Scientific American, vol. 250, No. 4, Apr., 1984, pp. 118-129.

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