Neural .alpha.-catenin

Details Neural .alpha.-catenin Neural .alpha.-catenin

1993-07-22

1995-11-28

Furman, Keith C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4353201, C12N 1509, C12N 1512

Patent

active

054709660

ABSTRACT:
To provide a new catenin concerning with the function of cell-cell adhesion, a gene encoding said catenin, and a use of said gene.
Isolated neural .alpha.-catenin. A gene encoding neural .alpha.-catenin. A method of producing neural .alpha.-catenin by the method of genetic engineering. A method of controlling the function of cell-cell adhesion by using said gene. Antibodies capable of recognizing neural .alpha.-catenin. Amino acid sequense of said neural .alpha.-catenin and nucleotide sequence of said gene are also determined.

REFERENCES:
Cell, vol. 70, pp. 293-301, Jul. 24, 1992, "Identification of a Neural .alpha.-Catenin as a Key Regulator of Cadherin Function and Multicellular Organization".
Herrenknecht et al. 1991. Proc. Natl. Acad. Sci. 88:9156-9160.
Nagafuchi et al. 1991. Cell 65:849-857.

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