Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-05-09
2006-05-09
Chernyshev, Olga N. (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S388100, C530S388220, C530S389100, C530S391300, C424S139100, C424S141100, C424S143100, C424S178100, C435S007100
Reexamination Certificate
active
07041806
ABSTRACT:
The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
REFERENCES:
patent: 93/16178 (1993-08-01), None
patent: 97/14424 (1997-04-01), None
Culotti JG. Database Medline on Dialog, US National Library of Medicine, (Bethesda, MD, USA), No. 08202090 95037661. ‘Axon Guidance mechanisms in Caenorhabditits elegans’, Current Opinion in Genetics and Developments, abstract, Aug. 1994, vol. 4, No. 4, pp. 587-595.
Hinck, L. et al. “Vertebrate homologs of C. elegans UNC-5 are candidate netrin receptors.” Soc. For Neuroscience Abstracts, vol. 22, No. 1-3, 1996 p. 1470.
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Aekerman et al. Nature 1997, 386:838-42.
Leonardo, E. David et al: “Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors.” Nature (London), vol. 386, No. 6627, Apr. 24, 1997, pp. 833-838.
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Hinck Lindsay
Keino-Masu Kazuko
Leonardo E. David
Masu Masayuki
Tessier-Lavigne Mark
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