Netrin receptors

Details Netrin receptors Netrin receptors

2011-04-05

2011-04-05

Chernyshev, Olga N (Department: 1649)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S069100, C435S320100, C435S325000, C435S007100, C514S001100

Reexamination Certificate

active

07919588

ABSTRACT:
The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
patent: 93/16178 (1993-08-01), None
patent: 97/14424 (1997-04-01), None
Culotti JG. Database Medline on Dialog, US National Library of Medicine, (Bethesda, MD, USA), No. 08202090 95037661. ‘Axon Guidance mechanisms inCaenorhabditis elegans’, Current Opinion in Genetics and Development, abstract, Aug. 1994, vol. 4, No. 4, pp. 587-595.
Hinck, L. et al. “Vertebrate homologs ofC. elegansUNC-5 are candidate netrin receptors.” Soc. For Neuroscience Abstracts, vol. 22, No. 1-3, 1996 p. 1470.
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Leonardo, E. David et al: “Vertebrate homologues ofC. elegansUNC-5 are candidate netrin receptors.” Nature (London), vol. 386, No. 6627, Apr. 24, 1997, pp. 833-838.
Leung-Hagesteijn et al., Cell, 71:289-99, 1992.
Wilson, R.K., “yf49e09.r1 Soares infant brain 1NIBHomo sapienscDNA clone Image:25300 5-, mRNA sequence,” GenBank Accession No. R11880, Online, 2pgs. (Apr. 11, 1995).
Wilson, R.K., “yo80g05.s1 Soares adult brain N2b4HB55YHomo sapienscDNA clone Image:184280 3-, mRNA sequence,” GenBank Accession No. H43716, Online, 2pgs. (Jul. 31, 1995).
Wilson, R. K., “yhO8c06.r2 Soares infant brain 1NIBHomo sapienscDNA clone Image:42591 5-, mRNA sequence,” GenBank Accession No. R67163, Online, 2 pgs. (May 30, 1995).

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