Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-02-19
1999-08-17
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 691, 4353201, 435325, 536 235, G01N 3353, C12N 1512
Patent
active
059392711
ABSTRACT:
The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed vertebrate unc-5 gene, vertebrate UNC-5-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceuticai industry.
REFERENCES:
Culotti JG. Database Medline on Dialog, US National Library of Medicine, (Bethesda, MD, USA), No. 08202090 95037661. `Axon Guidance mechanisms in Caenorhabditits elegans`, Current Opinion in Genetics and Development, abstract, Aug. 1994, vol. 4, No. 4, pp. 587-595.
Aekerman et al Nature 386 (1997) 838-842.
Leving et al Cell 71 (1992) 289-299.
Sambrook et al "Molecular Cloning, A Laboratory Approach" 2nd edition, Cold Spring Harbor Laboratory Press, USA pp. 8.46-8.47;9.2-9.3;16.3-16.4, 17.2.
Genbank Accession #R11880.
Genbank Accession #H43716.
Genbank Accession #R67163.
Hinck Lindsay
Keino-Masu Kazuko
Leonardo E. David
Masu Masayuki
Tessier-Lavigne Mark
Allen Marianne P.
Osman Richard Aron
The Regents of the University of California
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