Nerve growth induction, stimulation and maintenance and enzyme p

Details Nerve growth induction, stimulation and maintenance and enzyme p Nerve growth induction, stimulation and maintenance and enzyme p

1995-10-12

1997-09-09

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 2, 530350, A61K 3800, A61K 3827

Patent

active

056657064

ABSTRACT:
A composition comprising nerve growth factor and 2-amino-1,1,3-tricyano-1-propene useful for the induction, stimulation, and maintenance of nerve growth, and methods of potentiating choline O-acetyltransferase and tyrosine hydroxylase by 2-amino-1,1,3-tricyano-1-propene are disclosed.

REFERENCES:
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patent: 3311539 (1967-03-01), Eberts
patent: 4287184 (1981-09-01), Young
patent: 5023238 (1991-06-01), DaVanzo et al.
patent: 5194426 (1993-03-01), DaVanzo et al.
R. T. Houlihan and J. P. DaVanzo, Experimental Neurology, 10, 183 (1964) published in the U.S. and entitled "Nerve Growth-Promoting Properties of 1,1,3-Tricyano-2-Amino-1-Propene".
L. A. Green and E. M. Shooter, Ann. Rev. Neurosci., 3, 353 (1980) published in the U.S. and entitled "The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action".
B.A. Yankner and E.M. Shooter, Ann. Rev. Biochem., 51, 845 (1982) published in the U.S. and entitled "The Biology and Mechanism of Action of Nerve Growth Factor".
F. Hefti and W.J. Weiner, Annals of Neurology, 20, 275 (1986) published in the U.S. and entitled "Nerve Growth Factor and Alzheimer's Disease".
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S. Varon, et al., Biochemistry, 6, 2202 (1967) published in the U.S. and entitled "The Isolation of the Mouse Nerve Growth Factor Protein in a High Molecular Weight Form".
B.K. Schrier and L. Shuster, J. Neurochemistry, 14, 977 (1967) published in the U.S. and entitled "A Simplified Radiochemical Assay for Choline Acetyltransferase".
T. Nagatsu, et al., Analyt. Biochem. 9, 122 (1964) published in the U.S. and entitled "A Rapid and Simple Radioassay for Tyrosine Hydroxylase Activity".
J.P. DaVanzo, et al., Archive Int. Pharmacodyn, 41, 299 (1963) published in the U.S. and entitled "Action of 1,1,3-Tricyano-2-Amino-1-Propene on Neuromuscular Transmission".
H. Gnahn, et al., Developmental Brain Research, 9, 45 (1983) published in the U.S. and entitled "NGF-Mediated Increase of Choline Acetyltransferase (ChAT) in the Neonatal Rat Forebrain: Evidence for a Physiological Role of NGF in the Brain?".
S. Halegous and J. Patrick, Cell, 22, 571 (1980) published in the U.S. and entitled "Nerve Growth Factor Mediates Phosphorylation of Specific Proteins".
B.K. Schrier, et al., The Pharmacologist, 30, 128.10 (1988) received Sep. 27, 1988, published in the U.S. and entitled "Triap is Trophic for Cultured Peripheral Neurons".
J.P. DaVanzo, et al., The Pharmacologist, 30, 128.2 (1988) received Sep. 27, 1988, published in the U.S. and entitled "Induction and Potentiation of Neurite Outgrowth in the PC-12 Cell Line by 1, 1, 3 Tricyano-2-Amino-1-Propene".
J.W. Paul and J.P. DaVanzo, The Pharmacologist, 30, 59.9 (1988) received Sep. 27, 1988, published in the U.S. and entitled "Induction of Choline Acetyltransferase, Tyrosine Hydroxylase, and Ornithine Decarboxylase by 1,1,3-Tricyano-2-Amino-1-Propene in the PC-12 Cell Line".
J.W. Paul and J.P. DaVanzo, Society for Neuroscience, 346.10 Oct. 29-Nov. 3, 1989, published in the U.S. and entitled "1,1,3, Tricyano-2-Amino-1-Propene Potentiates Nerve Growth Factor-Induced Protein Phosphorylation in the PC-12 Cell Line".
Principles of Neural Development, ed. D. Purves and L.W. Lichtman, Chapter 7, pp. 162-164.

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