Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-05-29
2000-06-06
Wortman, Donna C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 74, 435 15, 435194, 436536, 530399, G01N 33567
Patent
active
060717092
ABSTRACT:
The present invention relates to a complex comprising nerve growth factor (NGF) and trk proto-oncogene protein and a complex comprising neurotrophic factors, NT-3 or BDNF, and trkB proto-oncogene protein. The present invention also relates to methods for detecting the presence of NGF, NT-3 or BDNF neurotrophic factors and trk and trk-related proto-oncogene receptors. The present invention further relates to methods that may be used in diagnostics and therapeutics for neurodegenerative diseases such as Alzheimer's and Huntington's by detecting complexes comprising NGF or NGF related neurotrophic factors bound to the product of the tyrosine kinase trk or related trk proto-oncogene family member.
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Kaplan et al. "Tyrosine Phosphorylation and Kinase Activity of the trk Proto-Oncongene Product Induced by NGF", Nature, 350(6314):158-160, 1991.
Klein et al. "trkB, a Novel Tyrosine Protein Kinase Receptor Expressed During Mouse Neural Development", EMBO Journal, 8(12):3701-3709, 1989.
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Hefti et al. "Neurotropic Strategies in Neurodegenerative Disease", UCLA Symposium on Advances in Understanding Neurodegenerative Disorders, Jan. 1992.
Kaplan David
Martin-Zanca Dionisio
Parada Luis F.
Soppet Dan
The United States of America as represented by the Department of
Wortman Donna C.
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