Nerve growth factor production accelerators and compositions for

Details Nerve growth factor production accelerators and compositions for Nerve growth factor production accelerators and compositions for

1994-02-22

1996-12-31

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

055894810

ABSTRACT:
Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of Peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolineguinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neuropathy, etc.

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The Journal of Neuroscience vol. 12, No. 6, Jun. 1992, pp. 2362-2369 Elias Aizenman et al. "Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl D-aspartate receptor redox modulatory site'" *abstract*.
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