Nerve-derived transglutaminase enzyme

Details Nerve-derived transglutaminase enzyme Nerve-derived transglutaminase enzyme

1995-06-07

1998-11-24

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Transferases

435 681, 435193, A61K 3845

Patent

active

058402950

ABSTRACT:
The invention provides a new nerve-derived transglutaminase enzyme that converts immune-derived IL-2 to dimeric IL-2 having oligodendrocyte cytotoxic activity. Both the nerve-derived transglutaminase and the dimeric mammalian, e.g. human, IL-2, are for use as active ingredients in pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals.

REFERENCES:
patent: 5514573 (1996-05-01), Yasueda et al.
patent: 5514579 (1996-05-01), O'Hara et al.

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