Neplanocin A derivatives

Details Neplanocin A derivatives Neplanocin A derivatives

1985-09-16

1986-09-23

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

435122, C07D47332

Patent

active

046136665

ABSTRACT:
Neplanocin A derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or benzoyl, R.sub.3 is hydrogen or OR.sub.8, R.sub.5 is hydrogen or acetyl, R.sub.6 is hydrogen, acetyl or benzoyl, when R.sub.3 is hydrogen, R.sub.4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, and when R.sub.3 is OR.sub.8, R.sub.4 is hydrogen, R.sub.8 is hydrogen or acetyl, or R.sub.8 and R.sub.5 together form benzylidene, and at least one of R.sub.8, R.sub.5 and R.sub.6 is other than hydrogen. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A, and hence are useful as antitumor agents.

REFERENCES:
patent: 4138562 (1979-02-01), Vince
patent: 4268672 (1981-05-01), Vince
patent: 4321376 (1982-03-01), Otani et al.
patent: 4345078 (1982-08-01), Hofer et al.
patent: 4423218 (1983-12-01), Otani et al.
Chemical Abstracts, Tenth Collective Index, vols. 86-95, 1977-1981, pp. 17437-17438.
Ohgi et al., Chemical Abstracts, vol. 88(23), Abst. No. 170,420w, Jun. 5, 1978.

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