Neostatins

Details Neostatins Neostatins

2006-02-01

2010-02-16

Leavitt, Maria (Department: 1633)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023500, C435S320100, C435S325000

Reexamination Certificate

active

07662945

ABSTRACT:
The invention provides fragments of type XVIII collagen termed neostatins, and methods for their use in the treatment of ophthalmological disorders associated with angiogenesis.

REFERENCES:
patent: 6630448 (2003-10-01), O'Reilly et al.
patent: 2003/0077289 (2003-04-01), Wang
Chang et al., Funtional Characterization of the 28 kDa Endostatin-spanning fragment of collagen XVIII in Mouse cornea. Invest Ophthalmol Vis Sci 2003; 44 E-Abstract 832.
Brown MD, et al., Gene delivery with synthetic (non viral) carriers. Int J Pharm. Oct. 23, 2001;229(1-2):1-21.
Zabner et al., Cellular and molecular barriers to gene transfer by a cationic lipid.J Biol Chem. Aug. 11, 1995;270(32):18997-9007.
Lechardeur et al., Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer.Gene Ther. Apr. 1999;6(4):482-97.
Colorado et al., “Anti-angiogenic cues from vascular basement membrane collagen” Cancer Res. 60:2520-2526 (2000).
Felbor et al., “Secreted cathepsin L generates endostatin from collagen XVIII” EMBO J. 19:1187-1194 (2000).
Ferreras et al., “Generation and degradation of human endostatin proteins by various proteinases” FEBS Lett. 486:247-251 (2000).
Halfter et al., “Collagen XVIII is a basement membrane heparan sulfate proteoglycan” J. Biol. Chem. 273:25404-25412 (1998).
Javaherian et al., “Laminin modulates morphogenic properties of the collagen XVIII endostatin domain” J. Biol. Chem. 277:45211-45218 (2002).
Kato et al., “Diminished corneal angiogenesis in gelatinase A-deficient mice” FEBS Lett. 508:187-190 (2001).
Kim et al., “Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction interaction with KDR/Flk-1” J. Biol. Chem. 277:27872-27879 (2002).
Kim et al., “Endostatin inhibits endothelial and tumor cellular invasion by blocking the activation and catalytic activity of matrix metalloproteinase” Cancer Res. 60:5410-5413 (2000).
Kure et al., “Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient mice” Invest. Ophthalmol. Vis. Sci. 44:137-144 (2003).
Lee et al., “Endostatin binds to the catalytic domain of matrix metalloproteinase-2” FEBS Lett. 519:147-152 (2002).
Lin et al., “Matrilysin cleavage of corneal collagen type XVIII NC1 domain and generation of a 28-kDa fragment” Invest. Ophthalmol. Vis. Sci. 42:2517-2524 (2001).
Marneros and Olsen, “The role of collagen-derived proteolytic fragments in angiogenesis” Matrix Biol. 20:337-345 (2001).
O'Reilly et al., “Endostatin: an endogenous inhibitor of angiogenesis and tumor growth” Cell 88:277-285 (1997).
Rehn et al., “Interaction of endostatin with integrins implicated in angiogenesis” PNAS USA 98:1024-1029 (2001).
Sasaki et al., “Structure, function and tissue forms of the C-terminal globular domain of collagen XVIII containing the angiogenesis inhibitor endostatin” EMBO J. 17:4249-4256 (1998).
Shichiri and Hirata, “Antiangiogenesis signals by endostatin” FASEB J. 15:1044-1053 (2001).
Turk et al., “Determination of protease cleavage site motifs using mixture-based oriented peptide libraries” Nature Biotechnology 19:661-667 (2001).
Wen et al., “The generation of endostatin is mediated by elastase” Cancer Res. 59:6052-6056 (1999).
Woessner Jr. And Taplin, “Purification and properties of a small latent matrix metalloproteinase of the rat uterus” J. Biol. Chem. 263:16918-16925 (1988).
Jun et al., “Prospects for gene therapy in corneal disease,”Eye,17:906-911 (2003).
Chang et al., “Cormeal neovascularization,” Curr. Opin. Ophthalmol., 12:242-249 (2001).

Affiliated with

Also associated with

Rating

Neostatins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neostatins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neostatins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4170715