Neomorphogenesis of cartilage in vivo from cell culture

Details Neomorphogenesis of cartilage in vivo from cell culture Neomorphogenesis of cartilage in vivo from cell culture

1989-04-17

1991-08-20

Cannon, Alan

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

623 10, 623 18, 424548, 514 21, 530840, A61F 228, A61F 218, C07C24500, A61K 3700

Patent

active

050411381

ABSTRACT:
Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells are proliferated in vitro until an adequate cell volume and density has developed for the cells to survive and proliferate in vivo. One advantage of the matrices is that they can be cast or molded into a desired shape, on an individual basis, so that the final product closely resembles a patient's own ear or nose. Alternatively, flexible matrices can be used which can be manipulated at the time of implantation, as in a joint, followed by remodeling through cell growth and proliferation in vivo. The cultured cells can also be maintained on the matrix in a nutrient media for production of bioactive molecules such as angiogenesis inhibiting factor.

REFERENCES:
patent: 4144126 (1979-03-01), Burbidge
patent: 4228243 (1980-10-01), Iizuka
patent: 4356261 (1982-10-01), Kuettner
patent: 4485097 (1984-11-01), Bell
patent: 4553272 (1985-11-01), Mears
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4627853 (1986-12-01), Campbell et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4713070 (1987-12-01), Mano
patent: 4757017 (1988-07-01), Cheung
patent: 4778749 (1988-10-01), Vasington et al.
patent: 4846835 (1989-07-01), Grande
Ptasinska-Urbanska, et al., Exp. Eye Res., vol. 24, No. 3, pp. 241-247 (1977).
J. M. Wozney, et al., Science 242, 1528-1534 (Dec. 16, 1988).
J. Upton, Plastic and Reconstructive Surgery 68(2), 166-174 (1981).
Alberts, et al., Molecular Biology of the Cell, 893 and 894 (1983).

Affiliated with

Also associated with

Rating

Neomorphogenesis of cartilage in vivo from cell culture does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neomorphogenesis of cartilage in vivo from cell culture, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neomorphogenesis of cartilage in vivo from cell culture will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1005863