Neomorphic ibuprofen and methods of using same

Details Neomorphic ibuprofen and methods of using same Neomorphic ibuprofen and methods of using same

1993-12-17

1995-11-14

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 53134

Patent

active

054668654

ABSTRACT:
A novel neomorphic form of ibuprofen, processes for preparing the ibuprofen, and method for administering the ibuprofen are provided. The neomorphic form is characterized by having a distinctively less bitter taste and causes less burning sensation upon swallowing. The neomorphic form of ibuprofen contains an amorphous ibuprofen. Tests indicate that the neomorphic form is less irritating to the gastrointestinal tract of animals upon administration.

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Vinod Labhasetwart, et al., Studies On Some Crystalline Forms of Ibuprofen, Drug Development and Industrial Pharmacy, 19(6), 631-641 (1993).

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