Neocarzinostatin derivatives and a process for producing the sam

Details Neocarzinostatin derivatives and a process for producing the sam Neocarzinostatin derivatives and a process for producing the sam

1978-03-16

1980-01-08

Levin, Stanford M.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

260DIG47, 525328, A61K 31785, C08F 832

Patent

active

041827520

ABSTRACT:
Neocarzinostatin derivatives having the formula; ##STR1## wherein N represents a neocarzinostatin residue, and R.sub.1 +R.sub.2 represents a residue of polystyrene-maleic acid copolymer having a molecular weight of 2,500 to 80,000. These neocarzinostatin derivatives are prepared by reacting neocarzinostatin with a polystyrene-maleic acid copolymer containing at least one maleic anhydride residue per molecule.
The neocarzinostatin derivatives exhibit anticarcinogenic activity.

REFERENCES:
patent: 3121043 (1964-02-01), Tobin et al.
patent: 3334022 (1967-08-01), Ishida et al.

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