Neo-tanshinlactone and analogs as potent and selective...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C549S279000, C549S276000

Reexamination Certificate

active

07495026

ABSTRACT:
Compounds of Formulas I-II are described,along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof.

REFERENCES:
Hua, D.H. et al.: An Improved procedure of the Pechmann condensation in the synthesis of 8-ethyltrimethoxy-6H-benzo[d]naphtho[1,2-b]-pyran-6-ones structurally related to the Aglycon of Gilvocarcins. J. Org. Chem. vol. 57, pp. 399-403, 1992.
RN 107516-42-7 ( see compound ).
Luo et al.; “Tanshinlactone, a Novel Seco-abietanoid fromSalvia miltiorrhiza” Chem. Pharm. Bull.34 3166-3168 (1986).
Wang et al.; “Antitumor Agents, 239, Isolation, Structure Elucidation, Total Synthesis, and Anti-Breast Cancer Activity of Neo-tanshinlactone fromSalvia miltiorrhiza” J. Med. Chem.47 5816-5819 (2004).
Wu et al.; “Cytotoxic Activities of Tanshinones Against Human Carcinoma Cell Lines”American Journal of Chinese MedicineXIX, 3-4, 207-216 (1991).
PCT International Search Report for International Application No. PCT/US05/07634; Mailed Jul. 27, 2005.
Rajitha, B. et al.: Synthesis of Coumestrol Analogs as possible Antifertility agents. Indian J. Chem. Aug. 1986, vol. 25B, pp. 872-873.
Ramesh, D, et al.: Studies on Polycyclic Thiaarenes. Indian J. Chem. Sep. 1986, vol. 25B, pp. 964-965.

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