Nematode vaccine

Details Nematode vaccine Nematode vaccine

1995-06-05

1998-03-31

Hutzell, Paula K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, 424 931, 4241841, 4242651, 530350, 435 691, 4352402, 4352523, 43525411, 4352542, 4353201, C12N 1511, C12N 1500, A61K 3900, C07K 1400

Patent

active

057340358

ABSTRACT:
Disclosed is a substantially purified antigen derived from a first parasitic nematode species which, when administered to a host animal, is capable of protecting the host animal from infestation by a second parasitic mematode species, wherein the first and second parasitic nematode species may be the same or different, and the antigen has an apparent molecular weight of 40 kD as determined by SDS-PAGE under reducing conditions.

REFERENCES:
patent: 4879213 (1989-11-01), Fox et al.
Friedlander et al., "Immunological Aspects of Murine Infection with the Rat Nematode Strongyloides ratti Sandground, 1925," Z Parasitenkd, 72: 493-509 (1986).
Kennedy et al., "Stage-Specific Secreted Antigens of the Parasitic Larval Stages of the Nemadote Ascaris," Immunology, 58: 515-522 (1986).
O'Donnell, "Attempts to Probe the Antigens and Protective Immunogens of Trichostrongylus, etc . . . ", International Journal of Parasitology, vol. 15, No. 2, pp. 129-136, 1985.
Van Regenmortel, "Structural and Functional Approaches to the Study of Protein Antigenicity", Immunology Today, vol. 10, No. 8, 1989, pp. 266-272.
P. Stern, "Predicting Antigenic Sites on Proteins", TIBTECH, vol. 9, May 1991, pp. 163-168.
Ibrahim et al., "Antigen Shedding from the Surface of the Infective Stage Larvae of Dirofilaria immitis", Parasitology, vol. 99, 1989, pp. 89-97.
Geysen et al., "Cognitive Features of Continuous Antigenic Determinants", Journal of Molecular Recognition, vol. 1, No. 1, 1988, pp. 32-41.
Lehninger in Biochemistry (1975) 2nd Edition, Worth Publishers NY, NY. p. 63.
Burgess et al (1990) J. Cell Biol. vol. 111, 2129-2138.
Lazar et al (1988) Mol. and Cell. Biol. vol. 8 (3), 1247-1252.

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