Nematode-extracted serine protease inhibitors and anticoagulant

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07H 2104

Patent

active

060404418

ABSTRACT:
Proteins which have activity as anticoagulants and/or serine protease inhibitors and have at least one NAP domain and are described. Certain of these proteins have factor Xa inhibitory activity and others have activity as inhibitors of factor VIIa/TF. These proteins can be isolated from natural sources as nematodes, chemically synthesized or made by recombinant methods using various DNA expression systems.

REFERENCES:
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4683293 (1987-07-01), Craig
patent: 4745051 (1988-05-01), Smith et al.
patent: 4777242 (1988-10-01), Nelles
patent: 4808537 (1989-02-01), Stroman et al.
patent: 4812405 (1989-03-01), Lair et al.
patent: 4818700 (1989-04-01), Cregg et al.
patent: 4837148 (1989-06-01), Cregg
patent: 4855231 (1989-08-01), Stroman et al.
patent: 4857467 (1989-08-01), Sreekrishna et al.
patent: 4879231 (1989-11-01), Stroman et al.
patent: 4882279 (1989-11-01), Cregg
patent: 4885242 (1989-12-01), Cregg et al.
patent: 4895800 (1990-01-01), Tschopp et al.
patent: 5002876 (1991-03-01), Sreeekrishma et al.
patent: 5004688 (1991-04-01), Craig et al.
patent: 5023236 (1991-06-01), Edgington et al.
patent: 5032516 (1991-07-01), Cregg
patent: 5106833 (1992-04-01), Broze et al.
patent: 5122465 (1992-06-01), Cregg et al.
patent: 5135868 (1992-08-01), Cregg
patent: 5166329 (1992-11-01), Cregg
patent: 5189019 (1993-02-01), Palladino et al.
patent: 5204261 (1993-04-01), Prevatt et al.
patent: 5239058 (1993-08-01), Vlasuk et al.
patent: 5239059 (1993-08-01), Zasloff et al.
patent: 5268273 (1993-12-01), Buckholz
patent: 5330901 (1994-07-01), Prevatt et al.
patent: 5427937 (1995-06-01), Cappelo et al.
patent: 5525477 (1996-06-01), Hassouna
patent: 5605671 (1997-02-01), Lyle et al.
Aoki, Y., et al., "Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin" Thrombosis and Hemostasis 71(4):452-455 (1994).
Babin et al., "The Isoinhibitors of Chymotrypsin/Elastase from Ascaris lumbricoides: The Primary Structure" Arch. of Biochem. and Biophy. 232(1):143-161 (1984).
Beaucage et al., "Deoxynucleoside Phosphoramidites-A New Class of Key Intermediates for Deoxypolynucleotide Synthesis" Tetrahedron Letters, 22(20):1859-1862 (1981).
Bernard, et al., "The Serine Protease Inhibitor Family from Ascaris Suum: Chemical Determination of the Five Disulfide Bridges" Arch. Biochem. Biophys., 303(2):367-376 (1993).
Bock, P.E. et al. "Isolation of Human Coagulation a-Factor X.sub.a by Soybean Trypsin Inhibitor-Sepharose Chromatography and Its Active-Site Titration with Fluorescein Mono-p-guanidinobenzoate" Archives of Biochem. Biophys. 273(2):375-388 (1989).
Bolivar et al., "Construction and Characterization of New Cloning Vehicles" Gene, 2:95-113 (1977).
Broach, J. et al., "Transformation In Yeast: Development of a Hybrid Cloning Vector and Isolation of the CAN1 Gene" Gene, 8:121-133 (1978).
Brown, E. et al., "Chemical Synthesis and Cloning of a Tyrosine tRNA Gene" Methods in Enzymology, 68, 109-151 (1979).
Bullock et al., "XL1-Blue: A High Efficiency Plasmid Transforming recA Escherichia coli Strain with Beta-Galactosidase Selection" Biotechniques 5(4):376-379 (1987).
Cairns et al., "Antithrombotic Agents in Coronary Artery Disease" Chest 102:456S-481S (1992).
Crameri et al., "Display of Biologically Active Proteins on the Surface of Filamentous Phages: a cDNA Cloning System for Selection of Functional Gene Products Linked to the Genetic Information Responsible for their Production" Gene, 137:69-75 (1993).
Cappello et al., "Ancylostoma Factor Xa Inhibitor: Partial Purification and Its Identification as a Major Hookworm-Derived Anticoagulant In Vitro" J. Infect. Diseases, 167:1474-1477. (1993).
Cappello et al., "Ancylostoma caninum anticoagulant peptide: A hookworm-derived Inhibitor of Human Coagulation Factor Xa," Proc. Natl. Acad. Sci. U.S.A. 92:6152-6156 (1995).
Carroll et al., "The Anticoagulant Effects of the Hookworm, Ancylostoma Ceylanicum: Observations on Human and Dog Blood In Vitro and Infected Dogs In Vivo" Thromb. Haemostas. (Stuttgart), 51(2):222-227 (1984).
Carson, "Computerized Analysis of Enzyme Cascade Reactions Using Continuous Rate Data Obtained with an ELISA Reader" Comput. Prog. Biomed 19:151-157 (1985).
Clements et al., "Secretion of Human Epidermal Growth Factor from Saccharomyces Cerevisiae Using Synthetic Leader Sequences" Gene 106:267-272 (1991).
Cohen, Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA Proc. Natl. Acad. Sci. USA, 69(8):2110-2114 (1972).
Crawford, et al., "Inhibition of Human Blood Clotting By Extracts of Ascaris Suum" J. Parasitol., 68(6):1044-1047 (1982).
Curtis, Biology Fourth ed. N.Y. Worth Publishers, Inc. pp. 500-501 (1983).
Depicker et al., "Nopaline Synthase: Transcript Mapping and DNA Sequence" J. Mol. Appl. Gen., 1(6):561-573 (1978).
Despreaux et al., "The dac A Gene of Bacillus Stearothermophilus Coding for D-Alanine Carboxypeptidase: Cloning, Structure and Expression in Escherichia coli and Pichia pastoris" Gene 131:35-41 (1993).
Fiers, et al., "Complete Nucleotide Sequence of SV40 DNA" Nature, 273:113-120 (1978).
Fuster, V. The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes New Engl. J. Med. 326(5):310-318 (1992).
Glaser-Wuttke, G., "Pore-Forming Properties of the Adsorption protein of Filamentous Phage fd" Biochem. Biophys. Acta, 985:239-247 (1989).
Glover, "Gene Cloning: The Mechanics of DNA Manipulation" 1-20 (1984).
Goeddel et al., "Synthesis of Human Fibroblast Interferon by E. coli" Nucleic Acids Res., 8(18):4057-4074 (1980).
Gold et al., "Evidence for a Rebound Coagulation Phenomenon After Cessation of a 4-hour Infusion of a Specific Thrombin Inhibitor in Patents with Unstable Angina Pectoris" JACC 21(5):1039-1047 (1993).
Grasberger et al., "High-Resolution Structure of Ascaris Trypsin Inhibitor in Solution: Direct Evidence for a pH-induced Conformational Transition in the Reactive Site" Structure, 2:669-678 (1994).
Hemker et al., "Feedback Mechanisms in Coagulation" Hemostasis 21:189-196 (1991).
Hirsh, J., "Heparin" N. Engl. J.Med 324(22):1565-1574 (1992).
Hitzeman et al., "Isolation and Characterization of the Yeast 3-Phosphoglycerokinase Gene (PGK) by an Immunological Screening Technique" J. Biol. Chem., 255(24):12073-12080 (1980).
Holland et al., "The Primary Structures of Two Yeast Enolase Genes" J. Biol. Chem., 256(3):1385-1395 (1981).
Houghten, "General Method for the Rapid-Solid Phase Synthesis of Large Numbers of Peptides: Specificity of Antigen-Antibody Interaction at the level of Individual Amino Acids" Proc. Natl. Acad. Sci., 82:5131-5135 (1985).
Hsiao, C.L. et al.,. "High-Frequency Transformation of Yeast of Plasmids Containing the Cloned Yeast ARG4 Gene" Proc. Natl. Acad. Sci. USA 76(8)3829-3833 (1979).
Huang et al., "The Molecular Structure of the Complex of the Complex of Ascaris Chymotrypsin/Elastase Inhibitor with Porcine Elastase" Structure 2:679-689 (1994).
Itakura et al., "Expression in Escherichia coli of a Chmically Synthesized Gene for the Hormone Somatostatin" Science 198:1056-1063 (1977).
Kasten, B.L., "Specimen Collection", Laboratory Test Handbook, 2nd Edition, Lexi-Comp Inc., Cleveland pp. 16-17 (Edit. Jacobs, D.S. et al. 1990).
Kessler, C. "The Pharmacology of Aspirin, Heparin, Coumarin and Thrombolytic Agents" Chest 99:97S-112S (1991).
Kurz, K.D., et al., "Rat Model of Arterial Thrombosis Induced by Ferric Chloride" Thromb. Res. 60:269-280 (1990).
Lawson et al., "A Model for the Tissue Factor Pathway to Thrombin" J. Biol. Chem. 269(37):23357-23366 (1994).
Levine et al., "Hemorrhagic Complications of Anticoagulant Treatment" Chest 102:352S-363S (1992).
Lidon et al., "Initial Experience with Direct Antithrombin Hirulog, in Unstable Angina" Circulation 88(4):1495-1501 (1993).
Loeb et al., "The Presence of a Substance Inhibiting the Coagulation of the Blood in Ancylostoma" Proc. Pathol. Soc. of Philadelphia, 7(6):173-178 (1904).
Lucchesi et al., "Prevention of Thrombosis and Rethrombosis and

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nematode-extracted serine protease inhibitors and anticoagulant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nematode-extracted serine protease inhibitors and anticoagulant , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nematode-extracted serine protease inhibitors and anticoagulant will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-731492

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.