Nell peptide expression systems and bone formation activity...

Details Nell peptide expression systems and bone formation activity... Nell peptide expression systems and bone formation activity...

2004-02-09

2009-06-09

Kemmerer, Elizabeth C. (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C436S069000, C436S169000, C436S169000, C436S169000, C536S023100, C536S023500, C536S024100

Reexamination Certificate

active

07544486

ABSTRACT:
The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.

REFERENCES:
patent: 4394370 (1983-07-01), Jefferies
patent: 4409332 (1983-10-01), Jefferies et al.
patent: 5385887 (1995-01-01), Yim et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5674725 (1997-10-01), Beersten et al.
patent: 5674844 (1997-10-01), Kuberasampath et al.
patent: 5763416 (1998-06-01), Bonadio et al.
patent: 5831058 (1998-11-01), Fujiwara et al.
patent: 5854207 (1998-12-01), Lee et al.
patent: 5916870 (1999-06-01), Lee et al.
patent: 5942496 (1999-08-01), Bonadio et al.
patent: 5948428 (1999-09-01), Lee et al.
patent: 6077987 (2000-06-01), Breitbart et al.
patent: 6083690 (2000-07-01), Harris et al.
patent: 6200606 (2001-03-01), Peterson et al.
patent: 6277972 (2001-08-01), Afar et al.
patent: 6352972 (2002-03-01), Nimni et al.
patent: 6413998 (2002-07-01), Petrie et al.
patent: 6462019 (2002-10-01), Mundy et al.
patent: 2003/0143688 (2003-07-01), Fujiwara et al.
patent: 2006/0111313 (2006-05-01), Ting
patent: 0 796 913 (1997-09-01), None
patent: WO 01/24821 (2001-04-01), None
patent: WO 03/006483 (2003-01-01), None
patent: WO 2004/024893 (2004-03-01), None
Gluzman, 1981, Cell 23:175, abstract only.
Liu et al., “Simultaneous Detection of Multiple Bone-Related mRNAs and Protein Expression during Osteoblast Differentiation: Polymerase Chain Reaction and Immunocytochemical Studies at the Single Cell Level”, Developmental Biology, vol. 166, pp. 220-234 (1994).
Zhang et al., “NELL-1 Overexpression Transgenic Mice Simulate Human Craniosynostosis”, Surgical Forum, vol. 52, pp. 576-578 (2001).
Supplementary European Search Rep. for 04709500.5-1222, mailed Feb. 22, 2008, 6 pgs.
Tessier et al., “Enhanced secretion from insect cells of a foreign protein fused to the honeybee melitten signal peptide”, Gene vol. 98, No. 2 pp. 177-183 (1991).
Li et al., “Control of Expression Glycosylation, and Secretion of HIV-1 gp120 by Homologous and Heterologous Signal Sequences”, Virology vol. 204, No. 1, pp. 266-278 (1994).
Sarkar et al. “Removal of 106 amino acids from the N-terminus of UDP-GIcNAc: α-3-D mannoside β-1, 2-N-acetylglucosaminyltrasferase I does not inactivate the enzyme”, Glycoconjugate J. vol. 15, No. 2, pp. 193-197 (1998).
Kuroda et al., “Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-Like Proteins NELL1 and NELL2”, Biochemical and Biophysical Res. Comm. Academic Press Inc. Orlando, vol. 265, pp. 79-86 (1999).
Elkins et al., Protein kinase C-binding protein NELL2 precursor (NEL-like protein) (Mouse) XP002467817 “Abstract” 3 pgs. (2000).
Kuroda et al., “Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase C”, Biochemical and Biophysical Res. Comm. Academic Press Inc. Orlando, vol. 265, pp. 752-757 (1999).
International Search Report for PCT/US04/03808 filed Feb. 9, 2004, mailed Sep. 19, 2006, 9 pgs.
Beck et al. “Rapid Publication TGF-β1Induces Bone Closure of Skull Defects.” J. ofBone Miner. Res.vol. 6, No. 11:1257-1265 (1991).
Bellows et al. “Determination of Numbers of Osteoprogenitors Present in Isolated Fetal Rat Calvaria Cells in Vitro.” Dev. Biol. 133, pp. 8-13 (1989).
Burger et al., “Osteoblast and Osteoclast Precursors in Primary Cultures of Calvarial Bone Cells.” Anat. Rec. Jan. 1986; 214(1): 32-40. Abstract only.
Chen et al. “Structure, Chromosomal Localization, and Expression Pattern of the MurineMagpGene,” J. Biol Chem. vol. 268, No. 36: 27381-27389 (1998).
Crawford et al. “Thrombospondin-1 is a Major Activator of TGF-β1in Vivo.” Cell, vol. 93:1159-1170 (1998).
Francois and Bier “Xenopus chordin and Drosophila short gastrulation Genes Encode Homologous Proteins Functioning in Dorsal-Ventral Axis Formation” Cell, vol. 80:19-20 (1995).
Gelbart, “Databases in Genomic Research” Science, vol. 282, Oct. 23, 1998.
Hoshi, K. et al., “Fibroblasts of Spinal Ligaments Pathologically Differentiate into Chondrocytes Induced by Recombinant Human Bone Morphogenetic Protein-2: Morphological Examinations for Ossification and Spinal Ligaments” Bone vol. 21, No. 2: 155-162 (1997).
Kim et al. “NELL-1 Enhances Mineralization in Fetal Calvarial Osteoblastic Cells.” Plastic Surgery, 599-601 (1999).
Kuroda and Tanizawa “Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein-Protein Interaction with Protein Kinase C1” Biochem Biophys Res. Commun. 265: 752-757 (1999).
Kuroda et al. “Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2” Biochem Biophys Res Comm. 265: 79-86 (1999).
Luce and Burrows “The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage”Gene231:121-126 (1999).
Opperman, et al., “TGF-β1, TGF-β2, and TGF-β3 Exhibit Distinct Patterns of Expression During Cranial Suture Formation and Obliteration In Vivo and In Vitro” J. of Bone and Mineral Research, vol. 12, No. 3: 301-310 (1997).
Piccolo et al. “Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4” Cell, vol. 86: 589-598 (1996).
Siris et al., “Design of NORA, the National Osteoporosis Risk Assessment program: A Longitudinal US Registry of Postmenopausal Women” Osteoporos Int. Suppl. 1: 62-69 (1998).
Takagi et al. “The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects” Ann Surg. vol. 196, No. 1: 100-109. Abstract only (1982).
Takami et al. “CA2+-ATPase Inhibitors and Ca2+-Ionophore Induce Osteoclast-like Cell Formation in the Cocultures of Mouse Bone Marrow Cells and Calvarial Cells” Biochemical and Biophysical Research Comm, vol. 237: 111-115 1997.
Tieu A. et al. “Identification of Human NEL-2 Associated with Premature Suture Fusion.” J Dent Res. 77(A):635, Abstract only (1998).
Ting et al. “Human NELL1 Expressed in Unilaterial Coronal Synostosis” J. of Bone and Mineral Res. vol. 14: 80-89 (1999).
Ting et al. “NELL-1 Enhances Mineralization in Fetal Calvarial Osteoblastic Cells.”J. Dent. Res.79:625 (2000).
Ting et al. “NEL-2 Expressed in Unilateral Prematurely Fusing and Fused Coronal Sutures.” J Dent Res. 77(B):2224 (1998) Abstract only.
Ting et al. “NEL-2 Gene is associated with bone formation in Craniosynostosis”, Plastic Surgery, 602-603 (no date).
Toriumi et al. “Mandibular Reconstruction With a Recombinant Bone-Inducing Factor.” Arch. Otolaryngol. Head Neck Surg. vol. 117: 1101-1112 (1991).
Watanabe, T.K. et al. “Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats.” Genomics, vol. 38, 273-276 (1996).
Wobus, “Potential of embryonic stem cells” Molecular Aspects of Medicine (2001), 22/3 (149-164) (Abstract only) 1 pg.
Yasko et al. “The Healing of Segmental Bone Defects, Induced by Recombinant Human Bone Morphogenetic Protein (rhBMP-2).” J. of Bone and Joint Surgery vol. 74A, No. 5: 659-670 (1992).
Zhang et al., “Graniosynostosis in transgenic mice overexpressing Nell-1” The J. of Clinical Investigation, vol. 110, No. 6 (2002).
International Search Report for PCT/US2008/054779, mailed Aug. 1, 2008, 11 pgs.
Aghaloo et al., “Nell-1-induced bone regeneration in calvarial defects”, Am. J. Pathol., vol. 169, pp. 903-915 (2006).
Cowan et al., “Nell-1 induce

Affiliated with

Also associated with

Rating

Nell peptide expression systems and bone formation activity... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nell peptide expression systems and bone formation activity..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nell peptide expression systems and bone formation activity... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4146826