NELL-1 enhanced bone mineralization

Details NELL-1 enhanced bone mineralization NELL-1 enhanced bone mineralization

2006-05-30

2006-05-30

Smith, Lynette R. F. (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S006120, C435S007800, C512S002000

Reexamination Certificate

active

07052856

ABSTRACT:
This invention pertains to the discovery that the human NELL-1 gene induces or upregulates bone mineralization. The NELL-1 gene or gene product thus provides a convenient target for screening for modulators of bone mineralization. In addition, NELL-1 can be used to facilitate repair of bone fractures and/or to generally increase bone density.

REFERENCES:
patent: 4394370 (1983-07-01), Jefferies
patent: 4409332 (1983-10-01), Jefferies et al.
patent: 5385887 (1995-01-01), Yim et al.
patent: 5486359 (1996-01-01), Caplan et al.
patent: 5674725 (1997-10-01), Beertsen et al.
patent: 5674844 (1997-10-01), Kuberasampath et al.
patent: 5763416 (1998-06-01), Bonadio et al.
patent: 5854207 (1998-12-01), Lee et al.
patent: 5916870 (1999-06-01), Lee et al.
patent: 5942496 (1999-08-01), Bonadio et al.
patent: 5948428 (1999-09-01), Lee et al.
patent: 6083690 (2000-07-01), Harris et al.
patent: 6200606 (2001-03-01), Peterson et al.
patent: 6352972 (2002-03-01), Nimni et al.
patent: 6413998 (2002-07-01), Petrie et al.
patent: 6462019 (2002-10-01), Mundy et al.
patent: WO 01/24821 (2001-04-01), None
Ting et al, Journal of Bone and Mineral Research, vol. 14, No. 1, 1999.
Liu et al, Developmental Biology, vol. 166, 1994, p. 220-234.
Siris et al, Osteoporos Int, 1998.
Gelbart, Science, vol. 282, Oct. 23, 1998.
Watanabe et al, Genomics 38, 273-276, 1996.
Kuroda et al, Biochemical and Biophysical Research Communications, 265, 752-757, 1999.
Zhang et al, The Journal of Clinical Investigation, Sep. 2002, vol. 110, No. 6.
Bellows et al (Developmental Biology, 133, 8-13, 1989.
Wobus (Molecular Aspects of Medicine (2001), 22/3 (149-164) (Abstract only).
Zhang et al (The Journal of Clinical Investigation, Sep. 2002, vol. 110, No. 6).
Bellows, C.G. et al. “Determination of Numbers of Osteoprogenitors Present in Isolated Fetal Rat Calvaria Cells in Vitro.” Dev. Biol. (1989) 133(1), pp. 8-13.
Burger, E.H. et al. “Osteoblast and Osteoclast Precursors in Primary Cultures of Calvarial Bone Cells.” Anat Rec. Jan. 1986; 214(1): 32-40. Abstract Only.
Hoshi, K. et al. Fibroblasts of Spinal Ligaments Pathologically Differential into Chondrocytes Induced by Recombinant Human Bone Morphogenetic Protein-2: Morphological Examinations for Ossification of Spinal Ligaments. Bone vol. 21, No. 2 (Aug. 1997): 155-162.
Opperman, L.A. et al. TGF-β1, TGF-β2, and TGF-β3 Exhibit Distinct Patterns of Expression During Cranial Suture Formation and Obliteration In Vivo and In Vitro. Journal of Bone and Mineral Research, vol. 12, No. 3 (1997): 301-310.
Takagi, K. et al. The reaction of the dura to bone morphogenetic protein (BMP) in repair of skull defects. Ann Surg. vol. 196, No. 1 (Jul. 1982): 100-109. Abstract only.
Takami, M. et al. CA2+-ATPase Inhibitors and Ca2+-Ionophore Induce Osteoclast-like Cell Formation in the Cocultures of Mouse Bone Marrow Cells and Calvarial Cells. Biochemical and Biophysical Research Communications, vol. 237, 1997: 111-115. (Article No. RC977090).
Tieu A. et al. “Identification of HumanNEL-2 Associated with Premature Suture Fusion.”J Dent Res.77(A):635, 1998 (Presented Mar. 4-7, 1998, Minneapolis, MN). Abstract Only.
Ting, K. et al. “NEL-2 Expressed in Unilateral Prematurely Fusing and Fused Coronal Sutures.”J Dent Res.77(B):2224, 1998 (in Abstact book, but withdrew from presentation because unable to make Jun. 24-27, 1998 trip to Nice, France). Abstract Only.
Watanabe, T.K. et al. “Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats.” Genomics, vol. 38, 273-276 (1996).
Beck et al. (1991) “Rapid Publication TGF-β1Induces Bone Closure of Skull Defects,”Bone Miner. Res.11:1257-1265.
Chen et al. (1998) “Structure, Chromosomal Localization, and Expression Pattern of the MurineMagpGene,”Biol Chem.268:27381-27389.
Crawford et al. (1998) “Thrombospondin-1 is a Major Activator of TGF-β1in Vivo.”Cell93(7):1159-1170.
Francois and Bier (1995) “ZenopuschordinandDrosophilia short gastrulationGenes Encode Homologous Proteins Funcitoning in Dorsal-Ventral Axis Formation.”Cell80(1):19-20.
Kim et al. (1999) “NELL-1 Enhances Mineralization in Fetal Calvarial Osteoblastic Cells.”Surgical ForumL:599-601.
Kuroda ad Tanizawa (1999) “Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein—Protein Interaction with Protein Kinase C1”Biochem Biophys Res Commun265(3):752-757.
Kuroda et al. (1999) “Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL 2”Biochem Biophys Res Commun265(1):79-86.
Luce and Burrows (1999) “The neuronal EGF-related genesNELL1andNELL2are expressed in hemopoietic cells and developmentally regulated in the B lineage”Gene231:121-126.
Piccolo et al. (1996) “Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4”Cell86(4):589-498.
Ting et al. (1999) “Human NELL1 Expressed in Unilaterial Coronal Synostosis”J. Bone Mineral Res.14(1):80-89.
Ting et al. (2000) “NELL-1 Enhances Mineralization in Fetal Calvarial Osteoblastic Cells.”J. Dent. Res.79:625.
Toriumi et al. (1991) “Manibular Reconstruction With a Recombinant Bone-Inducing Factor.”Arch. Otolaryngol. Head Neck Surg.117:1101-1112.
Watanabe et al. (1996) “Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.”Genomics 38(3):273-276.
Yasko et al (1992) “The Healing of Segmental Bone Defects, Induced by Recombinant Human Bone Morphogenetic Protein (rhBMP-2).” 5:659-670.
Kim, D et al. NELL-1 enhances mineralization in fetal calvarial osteoblastic cells. In Surgical Forum (1999), 50, 599-601. (Abstract only.).

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