Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Patent
1999-04-20
2000-02-29
Achutamurthy, Ponnathapu
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
435194, 435 4, 435 71, 435 6, C12Q 148, C12Q 100, C12Q 168, G01N 3353
Patent
active
06030801&
ABSTRACT:
The invention provides a human Nek 1-related protein kinase (NRPK) and polynucleotides which identify and encode NRPK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of NRPK.
REFERENCES:
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Isselbacher, K.J. et al., "Adrenergic Receptors," Harrison's Principles of Internal Medicine, 1:416-431, McGraw-Hill, New York, NY (1994).
Charbonneau, H. and Tonks, N.K., "1002 Protein Phosphatases?" Annu. Rev. Cell Biol., 8:463-493 (1992).
Letwin, K. et al., "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells," The EMBO J., 11(10):3521-3531 (1992).
Wilson, R. et al., (GI 1082109), GenBank Sequence Database (Accession Z68115), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, Nov. 26, 1997.
Database EMBL Nucleotide and Protein Sequences, Apr. 18, 1997 (1997-04-18), XP002110236, Hinxton, GB, AC = AA309645. EST180509 Jurkat T-cells V Homo sapiens cDNA 5' end. From 2644-3167.
Database EMBL Nucleotide and Protein Sequences, Apr. 18, 1997 (1997-04-18), XP002110237, Hinxton, GB, AC = AA307961. EST178864 Colon carcinoma (HCC) cell line II Homo sapiens cDNA 5' end similar to similar to protein kinase KIN3. From nt 355-857.
Database EMBL Nucleotide and Protein Sequences, Apr. 3, 1997 (1997-04-3), XP00211238, Hinxton, GB, AC = AA280818. Zs99c08.sl NCI.sub.-- CGAP.sub.-- GCBI Homo sapiens cDNA clone Image: 711758 3'.
Bandman Olga
Baughn Mariah
Corley Neil C.
Guegler Karl J.
Achutamurthy Ponnathapu
Incyte Pharmaceuticals Inc.
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