Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector
Patent
1995-08-09
1999-11-02
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
4242001, 4242341, 4242351, 4242491, 4242501, 424 932, 424 9321, 424 934, A61K 3900, A61K 3902, A61K 39095, A01N 6300
Patent
active
059765364
ABSTRACT:
Provided herein are mutant strains of Neisseria meningitidis which produce lipooligosaccharide (LOS) differing from the wild-type LOS in structure as well as the mutant LOS molecules and immunogenic compositions containing truncated LOS molecules from a Neisseria strain containing a genetically stable in a gene selected from the group consisting of genes encoding .alpha.-1,2-N-acetylglucosamine transferase and a gene homology to an Escherichia coli gene encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase. N. meningitidis NMB-559 harbors an insertion mutation in the gene encoding .alpha.-1, 2-N-acetylglucosamine transferase, and N. meningitidis NMB-469 harbors an insertion mutation in an nlaB gene, the protein product of which has significant amino acid sequence homology to the E. coli gene encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase.
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Kahler Charlene Marree
Stephens David S.
Emory University
Housel James C.
Ryan V.
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