Chemistry: analytical and immunological testing – Involving antibody fragments
Patent
1998-04-17
2000-06-27
Peselev, Elli
Chemistry: analytical and immunological testing
Involving antibody fragments
514 8, 514 54, 5303081, 530395, 536 187, 536 53, 536 553, 536 123, 536124, G01N 33563, A61K 3816, C12P 2108, C07K 100
Patent
active
060805897
ABSTRACT:
Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules to the polysaccharide backbone. The capsular polysaccharide is deacetylated and the heterobifunctional linker molecule is reacted with the deacetylated material and any residual amino groups are blocked by reaction with alkyl acid anhydride. The introduction of the linker molecules to the polysaccharide chain between the termini enables the polysaccharide to be linked to a carrier molecule, such as a protein, to enhance the immunogenicity of the polysaccharide. The conjugate molecule may be formulated as an immunogenic composition for raising antibodies in a host to the polysaccharide.
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Chong Pele
Kandil Ali
Klein Michel H.
Connaught Laboratories Limited
Peselev Elli
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