Neisseria gonorrhoeae vaccine

Details Neisseria gonorrhoeae vaccine Neisseria gonorrhoeae vaccine

1981-05-27

1984-04-17

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 88, 260112R, A61K 39095, C07C10352

Patent

active

044434316

ABSTRACT:
A vaccine affording protection against attachment of Neisseria gonorrhoeae (N.g.) to human cells, and consequent infection, is prepared from a fragment of pili protein isolated from gonococci. This fragment contains the shared antigens between pili from different N.g., in an exposed form.

REFERENCES:
patent: 4203971 (1980-05-01), Buchanon
patent: 4220638 (1980-09-01), Karkhonis
patent: 4330623 (1982-05-01), Karkhanis
Terrance G. Cooper, The Tools of Biochemistry, pp. 291-292, (1977).
William A. Pearch and Thomas M. Buchanan, "Attachment Role of Gonococcal Pili," J. Clin. Invest., 61: 931-943, (1978).
Jephcott, et al., "Neisseria Gonorrhoeae III, Demonstration of Presumed Appendages to Cells from Different Colony Types," ACTA Pathol. Microbiol Scand., Section B, 79, 437-439, (1971).
Swanson, et al., "Studies on Gonococcus Infection, I. Pili and Zones of Adhesion: Their Relation to Gonococcal Growth Patterns", Journal of Experimental Medicine, 134, 886-906, (1971).
Buchanan, et al., "Quantitative Determination of Antibody to Gonoccal Pili," Journal of Clinical Investigation, 52, 2896-2909, (1973).
Arko, et al., "Neisseria gonorrhoeae: Effects of Systematic Immunization of Resistance of Chimpanzees to Urethral Infection", Journal of Infectious Diseases, 130 160-164, (1974).
Buchanan, "Antigenic Heterogeneity of Gonococcal Pili," Journal of Experimental Medicine, 141, 1470-1475, (1975).
Buchanan and Pearce, "Pili as a Mediator of the Attachment of Gonococci to Human Erythrocytes", Infection and Immunity, 13, 1483-1489, (1976).
Hermodson, et al., "Neisseria Pili Proteins: Amino-Terminal Amino Acid Sequences and Identification of an Unusual Amino Acid", Biochemistry, 17, 442-445, (1978).
Buchanan, et al., "Pili and Principal Outer Membrane Protein of Neisseria gonorrhoeae: Immunochemical, Structural, and Pathogenic Aspects", Conference Proceedings on Immunobiology of Neisseria Gonorrhoeae, (1978), 145-154, (1978).
Buchanan, et al., "Attachment of Neisseria gonorrhoeae Pili to Human Cells, and Investigations of the Chemical Nature of the Receptor for Gonococcal Pili", Conference Proceedings on Immunobiology of Neisseria Gonorrhoeae, (1978), 242-249, (1978).
Brinton, et al., "Uses of Pili in Gonorrea Control: Role of Bacterial Pili in Disease, Purification and Properties of Gonococcal Pili and Progress in Development of a Gonococcal Pilus Vaccine for Gonorrhea", Conference Proceedings on Immunobiology of Neisseria Gonorrhoeae, (1978), 155-178, (1978).
Pearce and Buchanan, "Optimum Conditions and Quantitation of Adherence of Isolated Pili to Human Cells in Vitro", Journal of Clinical Investigation, 61, 931-943, (1978).
Buchanan, "Prospects and Problems for Development of a Vaccine Against Gonorrhea", Abstract from Embo Workshop on Genetics and Immunobiology of Pathogenic Neisseria, Hemavan, Sweden, (Jun. 1980).
Chen & Buchanan, "Structural Studies of a Gonococcal Pilus", Abstract from Embo Workshop on Genetics and Immunobiology of Pathogenic Neisseria, Hemaven, Sweden (Jun. 1980).

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