Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic

Details Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic

1986-09-12

1988-11-22

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

424 92, 435 68, 4351721, 4351723, 435253, 4353171, 435871, 436511, 436827, 530396, 536 27, 935 11, 935 12, 935 29, 935 72, A61K 39095, C07H 2100, C12N 1500, G01N 33571

Patent

active

047865920

ABSTRACT:
A bacterial lectin isolatable from Neisseria gonorrhoeae is disclosed. This lectin binds to gonococcal carbohydrates such as gangliotetraosylceramide, has a relative molecular weight of about 22,400 daltons, and an isolectric pH value in the range of about 6.1 to about 6.4. The disclosed lectin is useful as a constituent of a vaccine against gonorrhea and as a diagnostic means for gonorrhea. A method for isolating this lectin is also disclosed, as well as means for producing it.

REFERENCES:
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patent: 4115543 (1978-09-01), Wallace
patent: 4203971 (1980-05-01), Buchanan
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Perrollet, H. et al., The Lancet, vol. 1, No. 8492, 1269-1270 (May 31, 1986).
Heckels, J. E., J. Gen. Microbiol., vol. 99, Part 2, 333-341, (1977).
Buchanan, T. M. et al., Infection and Immunity, 32(3), 985-994 (Jun. 1981).

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