Negative immunomodulation of immune responses by ERp5

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07959916

ABSTRACT:
The present invention relates to methods of treating immune disorders and cancers. In particular the invention provides methods of inhibiting the negative immunomodulatory effects of ERp-5 on T cells and dendritic cells, in conjunction with other surface receptors.

REFERENCES:
patent: 6605278 (2003-08-01), Aggarwal
patent: 2005/0233391 (2005-10-01), Spies et al.
patent: WO 98/19167 (1998-05-01), None
patent: WO 2007/055926 (2007-05-01), None
Doubrovina et al., “Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma,”The Journal of Immunology, 171:6891-6899, 2003.
Bauer et al., “Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA,”Science, 285(5428):727-729, 1999.
Cosman et al., “ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor,”Immunity, 14:123-133, 2001.
Das et al., “MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function,”Immunity, 15(1):83-93, 2001.
Ellgaard and Ruddock, “The human protein disulphide isomerase family: substrate interactions and functional properties,”EMBO Rep., 6:28-32, 2005.
Gonzalez et al., “Immunobiology of human NKG2D and its ligands,”Curr. Topics Microbiol. Immunol., 298:121-138, 2006.
Groh et al.,“Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells,”Nat. Immun., 2(3): 255-260, 2001.
Groh et al., “Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB,”Proc. Natl. Acad. Sci. USA, 96(12):6879-6884, 1999.
Groh et al., “Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium,”Proc. Natl. Acad. Sci. USA, 93:12445-12450, 1996.
Groh et al., “Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity,”Nat. Immunol., 7:755-762, 2006.
Groh et al., “Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis,”Proc. Natl. Acad. Sci. USA, 100(16):9452-9457, 2003.
Groh et al., “Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation,”Nature, 419(6908):734-738, 2002.
Haridas et al., “TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase,”The Journal of Immunology, 161: 1-6, 1998.
Jordan and Gibbins, “Extracellular disulfide exchange and the regulation of cellular function,”Antioxid. Redox Signal, 8:312-324, 2006.
Kikuchi et al., “Functional analysis of human P5, a protein disulfide isomerase homologue,”J. Biochem., 132:451-455, 2002.
Li et al., “Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA,”Nat. Immunol., 2: 443-451, 2001.
Li et al., “Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell ligand,”Immunity, 10: 577-584, 1999.
Steinle et al., “Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family,”Immunogenetics, 53(4):279-87, 2001.
Tieng et al., “Binding ofEscherichia coliadhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA,”Proc. Natl. Acad. Sci. USA, 99(5):2977-82, 2002.
Turano et al., “Proteins of the PDI family: unpredicted non-ER locations and functions,”J. Cell Physiol., 193:154-163, 2002.
Office Communication, issued in International Application No. PCT/US2008/061236, dated Sep. 2, 2008.
Kaiser et al., “Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands,”Nature, 447(7143):482, 2007.
Mou et al., “The selective inhibition of beta 1 and beta 7 integrin-mediated lymphocyte adhesion by bacitracin,”Journal of Immunology, 161(11):6323-6329, 1998.
Zhang et al., “Imbalance of NKg2D and its inhibitory counterparts: How does tumor escape from innate immunity?,”International Immunopharmacology, 5(7-8):1099-1111, 2005.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Negative immunomodulation of immune responses by ERp5 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Negative immunomodulation of immune responses by ERp5, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Negative immunomodulation of immune responses by ERp5 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2682806

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.