Neem oil as a male contraceptive

Details Neem oil as a male contraceptive Neem oil as a male contraceptive

1993-09-02

1996-03-26

Jordan, Kimberly R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514450, 514468, 514680, 514841, A61K 3578, A61K 31335, A61K 3134, A61K 3112

Patent

active

055018556

ABSTRACT:
An alternate approach to vasectomy for long term male contraception following a single intra-vas.application of a traditional plant (Azadirachta indica) product having immunomodulatory properties is described. The intra-vas administration of neem oil to male rats resulted in a block of spermatogenesis without affecting the testosterone production; the seminiferous tubules, although reduced in diameter, appeared normal and contained mostly early spermatogenic cells. No antisperm antibody could be detected in the serum. Unilateral administration of neem oil in the vas resulted in a significant reduction of testicular size and spermatogenic block only on the side of application; the draining lymph node cells of the treated side also showed enhanced proliferative response to in vitro mitogen challenge. These results indicate that intra-vas application of neem oil is effective in blocking fertility in male mammals after a single injection.

REFERENCES:
patent: 5196197 (1993-03-01), Talwar et al.

Affiliated with

Also associated with

Rating

Neem oil as a male contraceptive does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Neem oil as a male contraceptive, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neem oil as a male contraceptive will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-914085