Needle penetrable and laser resealable lyophilization method

Details Needle penetrable and laser resealable lyophilization method Needle penetrable and laser resealable lyophilization method

2011-06-28

2011-06-28

Gravini, Stephen M. (Department: 3743)

Drying and gas or vapor contact with solids

Process

Gas or vapor pressure is superatmospheric

C034S417000, C034S285000, C034S381000, C034S401000, C514S001900, C514S011700, C600S008000, C600S532000, C424S085200, C435S325000, C435S326000, C604S024000, C604S019000

Reexamination Certificate

active

07966746

ABSTRACT:
A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.

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