Needle-less parenteral introduction device

Details Needle-less parenteral introduction device Needle-less parenteral introduction device

1997-03-12

2000-09-19

Azpuru, Carlos A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, A61F 202

Patent

active

061207861

DESCRIPTION:

BRIEF SUMMARY
FIELD OF THE INVENTION

The present invention relates to parenteral introduction devices and, in particular, to a device for intramuscular or subcutaneous administration of a pharmaceutically active composition.


BACKGROUND OF THE INVENTION

The parenteral route is preferred over oral ones in many occurrences. For example, when the drug to be administered would partially or totally degrade in the gastrointestinal tract, parenteral administration is preferred. Similarly, where there is need for rapid response in emergency cases, parenteral administration is usually preferred over oral.
Thus, while parenteral administration is desirable in many applications, as it is currently practiced, it presents substantial drawbacks. Probably the biggest drawback is the discomfort which it causes the patient to whom the drug is being administered. Parenteral preparations generally contain a large volume of liquid in which the drug is suspended or dissolved. Ratios of active ingredient to carrier commonly run from 1:100 to 1:1000. Especially where the active ingredient is poorly soluble or difficult to suspend, or when it has to be administered at high doses, or in both instances, a fairly large volume of liquid must be injected. The injection of the needle and the introduction of a fairly large volume of liquid cause parenteral administration to be more or less painful and at least disagreeable, for most people. Furthermore, depending on its nature, the solvent or the suspending agent may itself be a cause of pain.
A further disadvantage to administration of drugs in a liquid carrier is that the drugs are frequently not stable in the liquid. Therefore, the liquid and drug must be mixed substantially contemporaneously with injection. This can be of substantial disadvantage where, for example, many hundreds of people must be treated over a course of days in order to stem an epidemic.
Accordingly, it would be interesting to find a mode of administration avoiding the use both of a needle and of a liquid solution or suspension.
Parenterally administered solid compositions for use in the controlled release of a medicament are known and devices allowing direct injection of a medicament without need of a liquid are known such as, for example, trocars for implants of rods or pellets, and the device shown in European Patent Application No. 0292936 A3 for injection of a solid. However, trocars and the device of European Patent Application No. 0292936 A3 still require use of a needle.


SUMMARY OF THE INVENTION

The applicant has now discovered a comparatively inexpensive device for the ready administration of solid or semi-solid drugs by the parenteral route. The applicant's device avoids completely the need for a needle. The solid drug is injected directly through the skin of a patient, e.g., a human or animal, by a plunger which enters the skin only to the degree necessary to position the solid drug. The medicament is suitably made in the shape of the end of a toothpick, i.e., it has a pointed end which gradually tapers to a cylindrical portion. The medicament has sufficient structural strength so that it can penetrate through the skin into the subcutaneous layer when it is administered with the parenteral introduction device or the present invention. Thus, the drug penetrates the skin and there is no need for the expense of discomfort of a needle to administer the drug parenterally. The present invention also includes an automatic device that can contain a number of doses of medicament which can be administered to a series of patients, one after the other.
Other features and advantages of the invention will be apparent from the drawings, detailed description, and from the claims.


BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is an exploded view of the parenteral introduction device according to the present invention;
FIG. 2 shows the, parenteral introduction device of the present invention in its retracted form;
FIG. 3 shows the device of the present invention with a medicament having been parenterally introduced into a patient;

REFERENCES:
patent: 2589388 (1952-03-01), Hunter
patent: 3072121 (1963-01-01), Feldman
patent: 3572335 (1971-03-01), Robinson
patent: 4697575 (1987-10-01), Horowitz
patent: 4808166 (1989-02-01), Davidov
patent: 4820267 (1989-04-01), Harman
patent: 4871094 (1989-10-01), Gall et al.
patent: 4994028 (1991-02-01), Leonard et al.
patent: 5405324 (1995-04-01), Wiegerinck

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