Necrosis assay

Details Necrosis assay Necrosis assay

2009-03-06

2009-11-24

Saoud, Christine J (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

C435S070100, C435S007100, C435S287100, C435S325000

Reexamination Certificate

active

07622106

ABSTRACT:
A necrosis assays is performed with a cell expressing RIPK1 and RIP3 by (a) culturing the cell with a smac mimetic, caspase-8 inhibitor and TNF-α; and (b) detecting a resultant necrosis of the cell.

REFERENCES:
patent: 7309792 (2007-12-01), Harran et al.
He et al. (2009), Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α, Cell, vol. 137, pp. 1100-1111.
Petersen et al. (2007), Autocrine TNF-α,Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis, Cancer Cell, vol. 12, pp. 445-456.
Li et al. (2004), A Small Molecule Smac Mimic Potentiates TRAIL- and TNF-α-Mediated Cell Death, Science, vol. 305, pp. 1471-1474.

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