Near normal incidence optical assaying method and system having

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic

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436518, 436805, 436806, 436807, 435 71, 422 8205, 422 8207, 422 8208, 422 8209, 422 8211, 356318, 356356, 356445, G01N 33543, G01N 3353, G01N 2129, G01J 330

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059553782

ABSTRACT:
A method and system for optically assaying a substance in a sample using a sensing system having a diffraction grating sensor. A system and method are described that expose the sensor with a light beam at near normal angles of incidence and quantitatively measure the concentration of targeted substance by determining the angular separation between resulting anomaly angles. The present invention also contemplates a system and method that quantitatively measure the concentration of targeted substance by determining the wavelength separation between resulting anomaly wavelengths. Advantages of the present invention include increased sensitivity and less susceptibility to system drifts due to mechanical motion and thermal changes than conventional diffraction grating sensors.

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