Near-infrared raman spectroscopy for in vitro and in vivo detect

Details Near-infrared raman spectroscopy for in vitro and in vivo detect Near-infrared raman spectroscopy for in vitro and in vivo detect

1996-06-19

1999-11-23

Smith, Ruth S.

Surgery

Diagnostic testing

Detecting nuclear, electromagnetic, or ultrasonic radiation

436 64, 436171, 25033901, 25033906, 2503411, 356301, A61B 600

Patent

active

059916532

ABSTRACT:
Early diagnosis of cervical precancer is an important clinical goal. Optical spectroscopy has been suggested as a new technique to overcome limitations of current clinical practice. Herein, NIR Raman spectroscopy is applied to the diagnosis of cervical precancers. Using algorithms based on empirically selected peak intensities, ratios of peak intensities and a combination of Principal Component Analysis (PCA) for data reduction and Fisher Discriminant Analysis (FDA), normal tissues, inflammation and metaplasia were distinguishable from low grade and high grade precancers. The primary contributors to the tissue spectra appear to be collagen, nucleic acids, phospholipids and glucose 1-phosphate. These results suggest that near infrared Raman spectroscopy can be used effectively for cervical precancer diagnosis.

REFERENCES:
patent: 4556057 (1985-12-01), Hiruma et al.
patent: 4648892 (1987-03-01), Kittrell et al.
patent: 4675529 (1987-06-01), Kushida
patent: 4755684 (1988-07-01), Leiner et al.
patent: 4786813 (1988-11-01), Svanberg et al.
patent: 4832483 (1989-05-01), Verma
patent: 4913142 (1990-04-01), Kittrell et al.
patent: 4930516 (1990-06-01), Alfano et al.
patent: 4967745 (1990-11-01), Hayes et al.
patent: 4973848 (1990-11-01), Kolobanov et al.
patent: 5003977 (1991-04-01), Suzuki et al.
patent: 5009655 (1991-04-01), Daignault, Jr. et al.
patent: 5014707 (1991-05-01), Schwarz et al.
patent: 5026368 (1991-06-01), Adair
patent: 5034010 (1991-07-01), Kittrell et al.
patent: 5036853 (1991-08-01), Jeffcoat et al.
patent: 5038039 (1991-08-01), Wong et al.
patent: 5042494 (1991-08-01), Alfano
patent: 5046501 (1991-09-01), Crilly
patent: 5062431 (1991-11-01), Potter
patent: 5092331 (1992-03-01), Nakamura et al.
patent: 5104392 (1992-04-01), Kittrell et al.
patent: 5106387 (1992-04-01), Kittrell et al.
patent: 5115137 (1992-05-01), Andersson-Engels et al.
patent: 5125404 (1992-06-01), Kittrell
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5168162 (1992-12-01), Oong et al.
patent: 5174297 (1992-12-01), Dalkuzono
patent: 5192278 (1993-03-01), Hayes et al.
patent: 5199431 (1993-04-01), Kittrell et al.
patent: 5201318 (1993-04-01), Rava et al.
patent: 5251613 (1993-10-01), Adair
patent: 5261410 (1993-11-01), Alfano et al.
patent: 5280788 (1994-01-01), Janes et al.
patent: 5290275 (1994-03-01), Kittrell et al.
patent: 5293872 (1994-03-01), Alfano et al.
patent: 5303026 (1994-04-01), Strobl et al.
patent: 5304173 (1994-04-01), Kittrell et al.
patent: 5318023 (1994-06-01), Vari et al.
patent: 5318024 (1994-06-01), Kittrell et al.
patent: 5345941 (1994-09-01), Rava et al.
patent: 5348003 (1994-09-01), Caro
patent: 5348018 (1994-09-01), Alfano et al.
patent: 5408996 (1995-04-01), Salb
patent: 5419323 (1995-05-01), Kittrell et al.
patent: 5421337 (1995-06-01), Richards-Kortum et al.
patent: 5421339 (1995-06-01), Ramanujam et al.
patent: 5421346 (1995-06-01), Sanyal
patent: 5450857 (1995-09-01), Garfield et al.
patent: 5452723 (1995-09-01), Wu et al.
patent: 5467767 (1995-11-01), Alfano et al.
patent: 5507287 (1996-04-01), Palcic et al.
patent: 5552134 (1996-09-01), Morgan et al.
patent: 5596992 (1997-01-01), Haaland et al.
Angel et al., "Computer-Controlled Instrument for the Recovery of a Resonance Raman Spectrum in the Presence of Strong Luminescence," Anal. Chem., 56, 3000-3001, 1984.
Keller et al., "Application of Near-Infrared-Fourier Transform Raman Spectroscopy in Medical Research," J. Raman Spectrosc. 25(7-8):663-671, 1994.
Mizumo et al., "Near-Infrared Fourier Transform Raman Spectroscopic Study of Human Brain Tissues and Tumours," J. Raman Spectrosc., 25:25-29 (1994).
Van Duyne et al., "Mode-Locked Laser Raman Spectroscopy--A New Technique for the Rejection of Interfering Background Luminescence Signals," Anal. Chem., 46, 213-222, 1974.
Yu et al., "Laser Raman Spectroscopy of the Lens In-Situ Measured in an Anesthesized Rabbit," Curr. Eye Res., 1(10):615-618, 1982. Abstract only.
Alfano et al., "Optical Spectroscopic Diagnosis of Cancer in Normal Breast Tissues," J. Opt. Soc. Am. B., 6:1015-1023, May 1989.
Alfano et al., "Human Breast Tissues Studied by IR Fourier Transform Raman Spectroscopy," Lasers in the Life Sciences, 4(1):23-28, 1991.
Baraga et al., "In situ Optical Histochemistry of Human Artery Using Near Infrared Fourier Transform Raman Spectroscopy," Proc. Natl. Acad. Sci., 89:3473-3477, 1992.
Bot et al, "Raman Microspectroscopy of Fixed Rabbit and Human Lenses and Lens Slices: New Potentials," Exp. Eye Res., 49:161-169, 1989.
Brennan et al., "In situ Histochemical Analysis of Human Coronary Arteries by Raman Spectroscopy Compared with Biochemical Assay," In Advances in Fluorescence Sensing Technology, vol. II, ed. J.R. Lakowicz, SPIE Proceedings, 2388:105-109, 1995.
Clarke et al., "Laser Raman Spectroscopy of Calcified Atherosclerotic Lesions in Cardiovascular Tissue," Applied Optics, 26(16):3175-3177, 1987.
Dillon and. Goldstein, Principal Components Analysis, In: Multivariate Analysis, Methods and Applications, Chapter 2:23-392, 1984.
Feld et al., "Detection and Characterization of Human Tissue Lesions with Near Infrared Raman Spectroscopy," SPIE, 2388:99-104, 1995.
Frank et al., "Characterization of Human Breast Biopsy Specimens with Near-IR Raman Spectroscopy," Analytical Chemistry, 66(3)19-326, 1994.
Frank et al., "Raman Spectroscopy of Normal and Diseased Human Breast Tissues," Analytical Chemistry, 67(5):777-783, 1995.
Funfschilling and Williams, "CW Laser Wavelength Modulation in Raman and Site Selection Fluorescence Spectroscopy," Applied Spectroscopy, 30(4):443-446, 1976.
Kapadia et al., "Laser-Induced Spectroscopy of Human Colonic Mucosa: Detection of Adenomatous Transformation," Gastroenterology, 99:150-157, 1990.
Kramer et al., "Spectral Diagnosis of Human Coronary Artery: A Clinical System for Real Time Analysis," SPIE, 2395:376-382, 1995.
Lewis et al., "Raman Spectrometry and Neural Networks for the Classification of Wood Types--1," Spectrochimica Acta, 50A(11):1943-1958, 1994.
Liu et al., "Near-IR Fourier Transform Raman Spectroscopy of Norman and Atherosclerotic Human Aorta," Lasers in the Life Sciences, 4(3):257-264, 1992.
Liu et al., "Raman, Fluorescence, and Time-Resolved Light Scattering as Optical Diagnostic Techniques to Separate Diseased and Normal Biomedical Media," Journal of Photochemistry & Photobiology, 16(2):187-209, 1992. Abstract only.
Liu et al., "Raman, Fluorescence, and Time-Resolved Light Scattering as Opitical Diagnostic Techniques to Separate Diseased and Normal Biomedical Media," J Photochem. Photobiol. B: Biol., 16:187-209, 1992.
Mahadevan et al, "Optical Techniques for the Diagnosis of Cervical Precancers: A Comparison of Raman and Fluorescence Spectroscopies," SPIE, 2388:110-120, 1995.
Manoharan et al., "Raman Spectroscopy for Cancer Detection: Instrument Development and Tissue Diagnosis," SPIE, 2328, 128-132, 1994.
Manoharan et al., "Ultraviolet Resonance Raman Spectroscopy for Detection of Colon Cancer," Lasers in the Life Sciences, 6(4):217-227, 1995.
Mosier-Boss et al., "Fluorescence Rejection in Raman Spectroscopy by Sifted-Spectra, Edge Detection, and FFT Filtering Techniques," Applied Spectroscopy, 49(5):630-638, 1995.
Myric and Angel, "Elimination of Background in Fiber-Optic Raman Measurements," Applied Spectroscopy, 44(4):565-570, 1990.
Myrick et al., "Comparison of Some Fiber Optic Configurations for Measurement of Luminescence and Raman Scattering," Applied Optics, s29(9):1333-1344, 1990.
Nie et al., "Applications of Near-Infrared Fourier Transform Raman Spectroscopy in Biology and Medicine," Spectroscopy, 5(7):24-32 (1990).
Ozaki, "Medical Application of Raman Spectroscopy," Applied Spectroscopy Reviews, 24(3 & 4):259-312, 1988.
Puppels et al., "Laser Irradiation and Raman Spectroscopy of Single Living Cells and Chromosomes: Sample Degradation Occurs With 514.5 nm but Not With 660 nm Laser Light," Experimental Cell Research, 195(2):361-367 (1991).
Puppels et al., "Raman Microspectroscopic Approach to the Study of Human Granulocytes," Biophys. J., 60:1046-1056, 1991.
Redd et al., "Raman Spectroscopic Characteriza

Affiliated with

Also associated with

Rating

Near-infrared raman spectroscopy for in vitro and in vivo detect does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Near-infrared raman spectroscopy for in vitro and in vivo detect, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Near-infrared raman spectroscopy for in vitro and in vivo detect will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1233533