Near infrared fluorescent contrast agent and fluorescence...

Details Near infrared fluorescent contrast agent and fluorescence... Near infrared fluorescent contrast agent and fluorescence...

1999-09-16

2009-02-10

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Diagnostic or test agent produces in vivo fluorescence

C436S800000, C548S100000, C548S400000, C548S452000, C548S469000, C252S301220, C514S415000

Reexamination Certificate

active

07488468

ABSTRACT:
A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.

REFERENCES:
patent: 4839265 (1989-06-01), Ohno
patent: 4871656 (1989-10-01), Parton et al.
patent: 5298379 (1994-03-01), Adin et al.
patent: 5440042 (1995-08-01), Fabricius et al.
patent: 5672332 (1997-09-01), Fung et al.
patent: 5672333 (1997-09-01), Rajagopalan et al.
patent: 5709845 (1998-01-01), Rajagopalan et al.
patent: 5723204 (1998-03-01), Stefik
patent: 5747233 (1998-05-01), Lonsky et al.
patent: 5863753 (1999-01-01), Haugland et al.
patent: 6083485 (2000-07-01), Licha et al.
patent: 6083486 (2000-07-01), Weissleder et al.
patent: 6114350 (2000-09-01), Randall
patent: 6159657 (2000-12-01), Fleming et al.
patent: 6258340 (2001-07-01), Licha et al.
patent: 6319488 (2001-11-01), Licha et al.
patent: 6329531 (2001-12-01), Turner et al.
patent: 6441191 (2002-08-01), Lonsky et al.
patent: 6498945 (2002-12-01), Alfheim et al.
patent: 6663847 (2003-12-01), Achilefu et al.
patent: 2003/0202941 (2003-10-01), Achilefu et al.
patent: 2004/0213740 (2004-10-01), Achilefu et al.
patent: 0 577 189 (1994-01-01), None
patent: 0 580 145 (1994-01-01), None
patent: 0577189 (1994-01-01), None
patent: 0 591 820 (1994-04-01), None
patent: 0 800 831 (1997-10-01), None
patent: 06145539 (1992-11-01), None
patent: 406145539 (1994-05-01), None
patent: WO 91 18006 (1991-11-01), None
patent: WO 96 17628 (1996-06-01), None
patent: WO 97 13490 (1997-04-01), None
patent: WO 97 13810 (1997-04-01), None
patent: WO 97 40104 (1997-10-01), None
patent: WO 98 22146 (1998-05-01), None
patent: WO 98 47538 (1998-10-01), None
patent: WO 00 16810 (2000-03-01), None
Riefke et al., “In vivo characterization of cyanine dyes as contrast agents for near-infrared imaging”; Proceedings of the SPIE, US, SPIE, Bellinghan, VA; vol. 2927, p. 199-208.
Licha et al., “Synthesis and characterization of cyanine dye—poly(ethylene glycol) conjugates as contrast agents for in vivo fluorescence image”; Proceedings of the SPIE, US, SPIE; Bellingham, VA; vol. 3196, p. 98-102.
Licha et al., “Synthesis and characterization of cyanine dyes as contrast agents for near-infrared imaging”; Proceedings of the SPIE, US, SPIE; Bellingham, VA; vol. 2927, p. 192-198.
Office of Action of Aug. 3, 2005 in copending CIP, U.S. Appl. No. 10/149,917.
Office action dated Sep. 28, 2007 in pending U.S. Appl. No. 10/149,917, filed Oct. 17, 2002.
Office action dated Jun. 22, 2007 in pending U.S. Appl. No. 10/324,010, filed Dec. 20, 2002.
Office Action dated Jul. 9, 1002 in U.S. Appl. No. 10/149,917.
Licha et al “Synthesis and characterization of cyanine dyes as contrast agents for near-infrared imaging” Proceedings of the SPIE, US, SPIE, Bellingham, VA, vol. 2927, Sep. 9, 1996, pp. 192-198, XP002079648.
Office Action dated Mar. 17, 2008 issued in U.S. Appl. No. 10/149,917.
Office Action dated Dec. 21, 2007 issued in U.S. Appl. No. 10/324,010.

Affiliated with

Also associated with

Rating

Near infrared fluorescent contrast agent and fluorescence... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Near infrared fluorescent contrast agent and fluorescence..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Near infrared fluorescent contrast agent and fluorescence... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4096726