Natural tissue heart valve fixation process

Bleaching and dyeing; fluid treatment and chemical modification – Treatment of hides – skins – feathers and animal tissues – Internal tissues

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3 15, 128274, A61L 1700, C14C 300, C14C 1500, A61C 122

Patent

active

042472920

ABSTRACT:
A process for fixing a natural tissue heart valve whereby the valve has improved hydraulic performance is disclosed. The valve is first placed in glutaraldehyde with the valve cusps kept in the closed position by applying hydraulic pressure to the ventricular side of the valve. The valve is then trimmed and fitted to and sutured into a fabric covered plastic stent. An expandable tube is then placed axially within the valve and expanded to force the valve cusps into an open position. The expanded tube-valve-stent assembly is then placed in glutaraldehyde to further fix the valve and predispose the valve cusps to an open position.

REFERENCES:
patent: 3966401 (1976-06-01), Hancock et al.
patent: 3983581 (1976-10-01), Angell
patent: 4035849 (1977-07-01), Angell et al.
patent: 4050893 (1977-09-01), Hancock et al.
patent: 4090878 (1978-05-01), Hancock et al.
Broom "Fatigue-Induced Damage in Glutaraldehyde Preserved Heart Valve Tissue" J. Thorack & Card, vol. 76 (2) 202-211.
Biosis Abst., vol. 66, Jul. 15, 1978, 6843 Broom, "The Stress/Strain & Fatigue Behavior of Glutaraldehyde Preserved Heart-Valve Tissue".
Industrial Gums, Polysaccharides and their Derivatives, 2nd Ed., by Roy L. Whistler, p. 85.
Indian Textile Journal Utilization of Tamarind Seed Pectin in Textile Industries, Part III Potentialities of Pectin in Printing by G. R. Savur, (1956) pp. 309-311 and 33-35 (1955).

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