Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Reexamination Certificate
2000-06-14
2003-08-12
Spear, James M. (Department: 1625)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
C424S400000, C424S441000, C424S489000, C424S442000, C424S401000
Reexamination Certificate
active
06605296
ABSTRACT:
The invention relates to a preparation based on natural substances for internal and external use.
JP 6 070 746 A discloses a table vinegar which contains docosahexaenic acid and preferably 1 to 20% dried tuna fish extract. In addition, as claimed in JP 6 070 746 A, the table vinegar contains antioxidants such as tocopherol, lecithin, and/or catechin. The object of the composition of the table vinegar of JP 6 070 746 A is for the table vinegar and its products to have little fish smell and to have a good taste and aroma and good tactile sense. This moderates the irritation or the unpleasant fish smell. Medical applications and/or effects are not described.
EP 0 712 630 A2 relates to an oral composition for prevention of sun allergies. The composition is based on a carotinoid, a tocopherol, ascorbic acid, and selenium. Carotene and lycopene are used as the carotinoids. EP 0 712 630 A2 mentions the already known combination of antioxidants with vegetable oil as the adjuvant in the production of capsules for oral use. EP 0 712 630 A mentions lecithin solely as the adjuvant for capsule production. Medical applications and/or effects besides the action against sun allergies of the oral administration of the preparation of EP 0 712 630 A2 are not disclosed.
WO 95/21542 A1 discloses a beverage which is to be produced by the mixing of fruit juices and vegetable juices, oyster extract, glycyrrhizin, nonalcoholic red wine concentrate, wheat germ, soybean extract and seasonings. The beverage will contain provitamin A, vitamin A, vitamin E, vitamin C, trace elements, soluble fibers, flavonoids, glycyrrhizin, and taurine. It is also given in this citation that the red wine due to its flavonoid content has a preventative action against heart disease.
JP 630 00 257 A relates to a dried, sweet seed-corn product with 25 to 50% sugar, 1 to 25% soluble polysaccharides, 6 to 30% oil and 0.1 to 0.6% lecithin and tocopherol as the antioxidants. This is a product which can be taken orally and for which medical applications and/or effects are not validated.
U.S. Pat. No. 5,702,714 A relates to a composition for skin care which contains d-alpha-tocopherol oil, purcelline, (long chain and solid), and purcelline oil (a cetearyl octanoate) and pure silicic acid as the gelling agent for the oil, decyl oleate, squalane (brand name “Robane”) which is a saturated, aliphatic hydrocarbon, wheat germ glyceride, proto-lan 8, consisting of phospholipids, lipo-polypeptides and lipo-aminic acids, polyoxypropylene esters and guaiazulene, a camomile extract. For the preparation of U.S. Pat. No. 5,702,714 A an improvement of the constitution of the skin by “rejuvenation” is validated. In conjunction with the component squalane it is pointed out that squalane is a saturated derivative of squalene and can be obtained by hydrogenation of natural, unsaturated squalene (see Martindale, The Extra Pharmacopoeia, 31st edition, 1996, page 1411).
JP 9 077 633 A discloses cosmetic compositions containing borage grass oil, with delta-tocopherol, ascorbic acid esters and/or lecithin. The cosmetic composition of JP 9 077 633 A is intended to improve the moist feeling on the skin and at the time of use have a good spreading property. The composition is intended for use in various areas, for example, foodstuffs, cosmetics, medicine, clothing.
As is known, food is absorbed in the human organism both in the gastrointestinal tract and also through the skin (internal and external). Thus, in external use bioactive substances, for example local rheumatism preparations or local varicose vein preparations, are absorbed into the human organisms.
According to the latest statistics on the causes of death in Germany, almost half of fatalities die from cardiac-circulatory diseases. Cancer is the second most frequent cause of death in Germany with almost one fourth. Cardiac-circulatory disease and cancer are thus responsible for almost three fourths of all causes of death. The numbers are similar in Austria. The urgency of effective prevention can be recognized from this.
The object of the invention is to make available a preparation of the initially mentioned type which has been prepared for example as a food supplement and which has advantageous physiological effects.
As claimed in the invention the preparation contains in a carrier substance as important components lecithin, red wine extract and D-alpha-tocopherol acetate, and optionally pectin in an amount of at least 0.50 parts by weight each.
Additional components in the food supplement can be the following: squalene, beta carotene, lycopene green tea extract, garlic extract, genistein, D-limonene, bisabolol (levomenol), leucocyanidol (pycnogenol), gingko biloba leaf extract, hawthorn extract, artichoke leaf extract, Blessed milkthistle fruit extract, ascorbic acid, B vitamins, olive leaf extract, escin, troxerutin, shitake mushroom extract (Lentinus edodes), frankincense extract (Boswellia), clawthorn extract, fish oil (salmon oil) concentrate, angurate extract and/or diosmine.
The B vitamins optionally contained in the preparation can be folic acid, vitamin B6, vitamin B12, nicotinamide, dexpanthenol, vitamin B1, vitamin B2, and/or biotin.
The preparation as claimed in the invention has beneficial effects on cardiac, circulatory and rheumatic conditions, acts preventively and strengthens the immune system against cancer.
It can be used for example preferably as a food supplement, as a biological, formula-free medication, body care preparation, healthy edible oil and healthy margarine.
The carrier substance can be a dairy product, margarine, fruit juice, olive oil, a vegetable juice, yeast, pectin or sorbite. The carrier substance can also be other substances such as cereals (for example, corn flakes) and other dry foods.
With respect to the components of the preparation as claimed in the invention, the following parts by weight always relating to the preparation as a whole; the following are listed:
Cold-pressed olive oil can form the carrier substance. The olive oil yields lipid-reducing, antiarteriosclerotic and anticancer effects. The high content of single unsaturated oleic acid which is present in cold-pressed olive oil is decisive for this purpose. The oleic acid significantly reduces the total cholesterol and the LDL cholesterol in the blood serum. Furthermore, the cold-pressed olive oil contains roughly 0.5% squalene which is an aliphatic triterpene, consisting of six isoprene units, Squalene has an antiinflammatory effect.
Lecithin is important to the extent that this component is a natural amphoteric emulsifier. Lecithin occurs in the cell membranes, in the lipoproteins of the blood plasma, in the liver, heart, kidneys, nerves, sperm and the bile, where it keeps the cholesterol together with bile acids in solution. Lecithin has a lipid-reducing effect when administered in a dose of a few grams. (See Hunnius, Pharmaceutical Dictionary [in German]. 8th edition, 1998, page 817).
Red wine extract (preferably 0.05 to 1.0 parts by weight) is important to the extent that it contains resveratrol as an important component. Resveratrol is 3,5,4′-trihydroxy-stilbene. Resveratrol is contained in larger amounts in the skin of blue wine grapes, in red wine and grape juice, in peanuts and mulberries. Resveratrol has been identified as an effective component in “Koyo-Kon” of folk medicine in China and Japan. Resveratrol is used to treat arteriosclerosis and acts against the tendency of the blood platelets to clump and reduces susceptibility to thrombosis. Red wine extract especially due to its content of resveratrol has protective effects against arteriosclerosis and cancer. Red wine with resveratrol protects the LDL particles in the blood much more strongly against oxidation than a comparable amount of likewise antioxidative vitamin E.
Free radicals and reactive oxygen compounds are involved in the formation of the most important common diseases such as cancer, arteriosclerosis and rheumatism. Conversely, antioxidants such as lecithin as a synergistic antioxidant, red wine extra
Evans Charesse
Numico Research B.V.
Spear James M.
Young & Thompson
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