Natural ligand of G protein coupled receptor RCC356 and uses...

Details Natural ligand of G protein coupled receptor RCC356 and uses... Natural ligand of G protein coupled receptor RCC356 and uses...

2011-08-30

2011-08-30

Reddig, Peter J (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S350000

Reexamination Certificate

active

08008023

ABSTRACT:
The invention relates to the identification of isovaleric acid as a natural ligand of the RCC356 G-protein coupled receptor (GPCR). The invention encompasses the use of the interaction of RCC356 polypeptides and isovaleric acid as the basis of screening assays for agents that modulate the activity of the RCC356 receptor. The invention also encompasses diagnostic and other assays performed based upon the RCC356/isovaleric acid interaction, as well as kits for performing diagnostic and screening assays.

REFERENCES:
patent: 2003/0105000 (2003-06-01), Pero et al.
patent: 2004/0005563 (2004-01-01), Mack et al.
Bowie et al. (Science, 1990, 247:1306-1310).
Skolnick et al. (Tibtech 18:34-39, 2000).
Ibragimova and Eade (Biophysical Journal, Oct 1999, vol. 77, pp. 2191-2198).
Burgess et al. (J of Cell Bio. 111:2129-2138, 1990).
Lazar et al. (Molecular and Cellular Biology, 1988, 8:1247-1252).
Scott et al. (Nature Genetics, 1999, 21:440-443).
NCBI Ref. Seq. NP—689643 (olfactory receptor 51E1, gi: 205277378, Mar. 2010).

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