Natural ligand for orphan G protein coupled receptor GPR86...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S007100, C435S007200

Reexamination Certificate

active

11216987

ABSTRACT:
The present invention is related to a method of detecting the dysregulation of GPR86 activity.

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patent: WO/00/31258 (2000-06-01), None
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Zhang et al., P2Y13: Identification and characterization of a novel G alpha i-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301: 705-713, May 2002.
Communi D. et al., “Receptors responsive to extracellular pyrimidine nucleotides” Trends in Pharmacological Sciences, 18(3):83-86 (Mar. 1, 1997).
Communi D. et al., “Cloning of a Human purinergic P2Y receptor coupled to phospholipase C and adenyl cyclase” Journal of Biological Chemistry 272(51):31969-31973 (Dec. 19, 1997).
Owman et al., Molecular cloning and tissue distribution of cDNA Encoding a Novel Chemoattractant-like Receptor, Biochem Biophys Res. Commun. Dec 18, 1997:241(2):390-4.
Samson et al., ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains, Eur. J. Immunol. May 1998; 28(5): 1689-700.

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