Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Reexamination Certificate
2006-10-17
2006-10-17
Mertz, Prema (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
Reexamination Certificate
active
07122633
ABSTRACT:
This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
REFERENCES:
patent: 4419446 (1983-12-01), Howley et al.
patent: 4473555 (1984-09-01), Nestor, Jr. et al.
patent: 4512922 (1985-04-01), Jones et al.
patent: 4518584 (1985-05-01), Mark et al.
patent: 5098702 (1992-03-01), Zimmerman et al.
patent: 5648467 (1997-07-01), Trinchieri et al.
patent: 5811523 (1998-09-01), Trinchieri et al.
patent: 0 123 289 (1984-10-01), None
patent: 0 155 476 (1985-09-01), None
patent: 0 188 864 (1986-07-01), None
patent: 0 357 067 (1990-03-01), None
patent: 0 433 827 (1991-06-01), None
patent: WO 85/05124 (1985-11-01), None
patent: WO 86/00639 (1986-01-01), None
patent: WO 87/04187 (1987-07-01), None
patent: WO 88/00206 (1988-01-01), None
patent: WO 88/08035 (1988-10-01), None
Mikayama et al. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060, 1993.
Voet et al. Biochemistry. John Willey & Sons, Inc., pp. 126-128 and 228-234, 1990.
Reiger et al. (1996) Glossary of Genetics and Cytogenetics, 4th edition, Springer-verlag, pp. 16-19.
Mikayama et al. Proc. Natl. Acad. Sci. USA vol. 90, pp. 10056-10060.
Voet et al. Biochemistry. John Wiley & Sons, Inc., pp. 126-128 and 228-234.
Better et al., “Escherichia coliSecretion of an Active Chimeric Antibody Fragment,”Science, 240:1041-1043 (1988).
Bowie et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science, 247:1306-1310 (1990).
Brunda, “Role of IL12 as an anti-tumour agent: current status and future directions,”Res. Immunol., 146:622-628 (1995).
Cohen, “IL-12 Deaths Explanations and a Puzzle,”Science270:908 (1995).
Casagli et al., “Purification of Recombinant Human Interleukin 1β Produced From Yeast,” Protein Purification:Micro to Macro, Proceedings of a Cetus-UCLA Sumposium, pp. 421-427 (1987).
Cuturi et al., “Independent Regulation of Tumor Necrosis Factor and Lymphotoxin Production by Human Peripheral Blood Lymphocytes,” J. Exp. Med., 165:1581-1594 (1987).
Devos et al., “Molecular Cloning of Human Interleukin 2 cDNA and its Expression inE. coli,” Nucleic Acids Research, 11(13): 4307-4323 (1983).
Fox, “No winners against AIDS,”Bio/Technology, 12:128 (1994).
Fujiwara et al., “A sequence of cellular and molecular events involved in IL12-induced tumour regression,”Res. Immunol., 146:638-644 (1995).
Gething et al., “Cell-surface expression of influenza haemagglutinin from a cloned DNA copy of the RNA gene,”Nature, 293:620-625 (1981).
Gough et al., “Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor,”The EMBO Journal, 4(3):645-653 (1985).
Honsik et al., “Lymphokine-activated killer cells targeted by monoclonal antibodies to the disialogangliosides GD2 and GD3 specifically lyse human tumor cells of neuroectodermal origin,”Proc. Natl. Acad. Sci., 83:7893-7897 (1986).
Henney et al., “Interleukin-2 augments natural killer cell activity,”Nature, 291:335-338 (1981).
Herberman et al., “Natural Killer Cells: Their Role in Defenses Against Disease,”Science, 214: 24-30 (1981).
Hersey et al., “Potentiation of Lymphocyte Responses by Monoclonal Antibodies to the Gangliodie GD3,”Cancer Res., 46:6083-6090 (1986).
Ichimura et al., “Characterization of Mouse Natural Killer Cell Activating Factor (NKAF) induced by OK-432: Evidence for interferon-and Interleukin 2-Independent NK Cell Activation,”The British Journal of Cancer, 50(1): 97-108 (1984).
Jacobs et al., “The thermal stability of oligonucleotide duplexes is sequence independent in tetraalkylammonium salt solutions: application to identifying recombinant DNA clones,”Nucl. Acids Res., 16:4637-4650 (1988).
Jang et al., “Initiation of Protein Synthesis by Internal Entry of Ribosomes into the 5′ Nontranslated Region of Encephalomyocarditis Virus RNA in Vivo,”J. of Virology, 63(4):1651-1660 (1989).
Katayama et al., “Comparison of Amino Acid Sequence of Bovine Coagulation Factor IX (Christmas Factor) with that of Other Vitamin K-Dependent Plasma Proteins,”Proceedings of the National Academy of Sciences, 76(10):4990-4994 (1979).
Kaufman et al., “Coamplification and Coexpression of Human Tissue-Type Plasminogen Activator and Murine Dihydrofolate Reductase Sequences in Chinese Hamster Ovary Cells,”Mol. Cell. Biol., 5(7):1750-1759 (1985).
Kaufman et al., “Amplification and Expression of Sequences Cotransfected with a Modular Dihydrofolate Reductase Complementary DNA Gene,”J. Mol. Biol., 159:601-621 (1982).
Kaufman, “Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors,”Proc. Natl. Acad. Sci. USA, 82:689-693 (1985).
Kaufman, “Selection and Coamplification of Heterologous Genes in Mammalian Cells,”Meth. Enzymol., 185:537-566 (1990).
Kobayashi et al., “Identification and Purification of Natural Killer Cell Stimulatory Factor (NKSF), A Cytokine with Multiple Biologic Effects on Human Lymphocytes,”The Journal of Experimental Medicine, 170(4):827-845 (1989).
Leammli, U.K., “Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4,”Nature, 227:680-685 (1970).
Lanier et al., “Interleukin 2 Activation of Natural Killer Cells Rapidly Induces the Expression and Phosphorylation of the Leu-23 Activation Antigen,”The Journal of Experimental Medicine, 167(5): 1572-1585 (1988).
Lathe, “Synthetic Oligonucleotide Probes Deduced from Amino Acid Sequence Data- Theoretical and Practical Considerations,”J. Mol. Biol., 183(1):1-12 (1985).
Lerner, “Tapping the immunological repertoire to produce antibodies of predetermined specificity,”Nature, 299:592-596 (1982).
Ling et al., “Human IL-12 p40 Homodimer Binds to the IL-12 Receptor but Does Not Mediate Biologic Activity,”The Journal of Immunology, 154(1): 116-127 (1995).
London et al., “Production of proliferation in vitro of resting human natural killer cells: IL2 induces into cell cycle most peripheral blood NK cells, but only a minor subset of low density T cells,”J. Immunol, 137:3845-3854 (1986).
Lusky et al., “Characterization of the bovine papilloma virus plasmid maintenance sequences,”Cell, 36:391-401 (1984).
Maniatis et al., Molecular Cloning (A Laboratory Manual), Cold Spring Harbor Laboratory, pp. 387-389 (1982).
Mattner et al., “The Interleukin-12 Subunit p40 Specifically Inhibits Effects of the Interleukin-12 Heterodimer,”European Journal of Immunology, 23(9): 2202-2208 (1993).
Metcalf , “The Molecular Biology and Functions of the Granulocyte-Macrophage Colony Stimulating Factors,”Blood, 67(2):257-267 (1986).
Miller et al., “An Insect Baculovirus Host-Vector System for High-Level Expression of Foreign Genes,” Genetic Engineering: Principles and Methods, 8:277-298 (1986).
Perussia et al., “The Fc receptor for lgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies,”J. Immunol., 133:180-189 (1984).
Perussia et al., “Preferential proliferation of natural killer cells among peripheral blood mononuclear cells cocultured with B lymphoblastoid cell lines,”Natural Immunity and Cell Growth Regulation, 6:171-188 (1987).
Petrányi et al., “Natural Killer Cells in Man: Genetic and Other Factors Regulating Their Activity,”Progress in Immunology V, 1169-1180 (1983).
Richard et al., “Cytokines Involved in the Augmentation of Murine Natural Killer Cell Activity by Pyrimidinones in
Clark Steven C.
Hewick Rodney
Kobayashi Michiko
Perussia Bice
Trinchieri Giorgio
Finnegan Henderson Farabow Garrett & Dunner LLP
Mertz Prema
The Wistar Institute
Wyeth
LandOfFree
Natural killer stimulatory factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Natural killer stimulatory factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Natural killer stimulatory factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3638237