Natural killer lytic associated protein

Details Natural killer lytic associated protein Natural killer lytic associated protein

1997-07-16

1999-11-09

Degen, Nancy

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 1447

Patent

active

059817054

ABSTRACT:
A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlytic associated protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed, as well as methods of using the product to enhance anti-tumor, anti-viral and anti-microbial activity of natural killer cells. A method of inhibiting expression of the gene product is also disclosed, which may be used to turn off immune responses in situations of graft rejection and autoimmune disorders. Furthermore, methods of treating tumors and viruses in humans have been developed.

REFERENCES:
Young et al. (1986) Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity. Cell 44:849-859, Mar. 1986.

Affiliated with

Also associated with

Rating

Natural killer lytic associated protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Natural killer lytic associated protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Natural killer lytic associated protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1457639