Natural killer cell-specific antigen and antibodies that identif

Details Natural killer cell-specific antigen and antibodies that identif Natural killer cell-specific antigen and antibodies that identif

1995-06-07

1998-07-28

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

4241401, 4241531, 4241831, 435 79, 435325, 435329, 4353431, 436518, 436548, 5303873, 5303875, 53038873, 5303911, 5303913, 5303917, A61K 33395, C07K 1628, G01N 33579

Patent

active

057861609

ABSTRACT:
A novel natural killer cell-specific molecule, designated as PEN5, consisting essentially of a glycoprotein pair called PEN5.alpha. and PEN5.beta., having apparent molecular weights of 120-150 and 210-245 kdal, respectively. Monoclonal antibodies, including immunoreactive fragments and derivatives thereof, that bind to unique epitopes present on this NK cell-specific molecule; hybridomas that produce the monoclonal antibodies; methods of using the antibodies and fragments and derivatives; and methods for detecting and/or removing natural killer cells from a sample containing a mixed population of cells are also provided.

REFERENCES:
patent: 4772552 (1988-09-01), Hercend et al.
patent: 4797475 (1989-01-01), Terasaki et al.
patent: 4831122 (1989-05-01), Buchsbaum et al.
patent: 5068223 (1991-11-01), Lipsky et al.
patent: 5169939 (1992-12-01), Gefter et al.
patent: 5215927 (1993-06-01), Berenson et al.
Baume et al., "Differential Responses to Interleukin 2 Define Functionally Distinct Subsets of Human Natural Killer Cell, "Eur. J. Immunol., 22:1-6 (1992).
Caterson et al., "Identification of a Monoclonal Antibody That Specifically Recognizes Corneal and Skeletal Keratan Sulfate, "J. Biol. Chem., 258(14):8848-8854 (1983).
Chou et al., "Structure of Sulfated Glucuronyl Glycolipids in the Nervous System Reacting with HNK-1 Antiboby and Some IgM Paraproteins in Neuropathy, "J. Biol. Chem., 261(25):11717-11725 (1986).
Antibodies: A Laboratory Manual, Harlow, D. L., Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1988, pp. 321-323 and pp. 626-629.
Lanier, et al., "The Relationship of CD16 (LEU-11) and LEU-19 (NKH-1) Antigen Expression on Human Peripheral Blood NK Cells and Cytotoxic T Lymphocytes, "J. Immunol., 136(12):4480-4486 (Jun. 15, 1986).
McCoy et al., "Carbohydrates in the Functions of Natural Killer Cells, "Glycobiology, 1(4):321-328 (1991).
Moretta et al., "Allorecognition by NK Cells: Nonself or no self ?, "Immunology Today, 13(8): 300-305 (1992).
Nagler et al., "Comparative Studies of Human FcRIII-Positive and Negative Natural Killer Cells, "J. Immunol., 143(10): 3183-3191 (Nov. 15, 1989).
Ohmori et al., "Sialyl SSEA-1 Antigen Carbohydrate Marker of Human Natural Killer Cells and Immature Lymphoid Cells, "Blood, 74(1):255-261 (1989).
Parkman, R., "The Biology of Bone Marrow Transplantation for Severe Combined Immune Deficiency, "Advances In Immunology, (Dixon, F.J., ed.), Academic Press, Inc., New York, vol. 49 p.381-411 (1991).
Perussia et al., "Antibody 3G8, Specific for the Human Neutrophil Fc Receptor, Reacts with Natural Killer Cells,"J. Immunol., 132(3):1410-1415 (Mar. 1984).
Phillips et al., "Ontogeny of Human Natural Killer (NK) Cells: Fetal NK Cells Mediate Cytolytic Function and Express Cytoplasmic CD3e, .delta.Proteins,"J. Exp. Med., 175:1055-1066 (Apr. 1992).
Ravetch et al., "Alternative Membrane Forms of Fc.gamma.RIII (CD16) on Human Natural Killer Cells and Neutrophils: Cell Type-Specific Expression of Two Genes That Differ in Single Nucleotide Substitutions,"J. Exp. Med., 170:481-497 (Aug. 1989).
Schubert, et al., "N17 Cluster Report: CD57, "Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, 1989.
Sharon, N., Complex Carbohydrates, Their Chemistry, Biosynthesis, and Functions, Addison-Wesley Publishing Company, Inc., Reading, Massachusetts, 1975, pp. 48-64.
Sorrell, et al., "Human Keratinocytes Contain Carbohydrates That Are Recognized by Keratan Sulfate-Specific Monoclonal Antibodies, "J. Invest. Dermatol., 95(3):347-352 (1990).
Stocks et al., Expression of the CD15 Differentiation Antigen (3-fucosyl-N-acetyl-lactosamine, Le.sup.x) on Putative Neutrophil Adhesion Molecules CR3 and NCA-160, Biochem. J. , 268:275-280 (1990).
Trinhieri, G., "Biology of Natural Killer Cells,", Advances in Immunology, vol. 47, 1989, pp. 187-376.
Young et al., "Identification of Ganglio-N-Tetraosylceramide, as a New Cell Surface Marker for Murine Natural Killer (NK) Cells,"J. Immunol., 124(1):199-201 (Jan. 1980).
Yu et al., "Murine Natural Killer Cells and Marrow Graft Rejection, "Annu. Rev. Immunol., 10:189-213 (1992).
Yokoyama, W.M., "The Ly-49 and NKR-P1 Gene Families Encoding Lectin-Like Receptors on Natural Killer Cells: The NK Gene Complex,"Annu. Rev. Immunol., 11:613-635 (1993).
Coulter Cytometry Catalogue; Monoclonal Antibodies, Reagents, Kits and Instruments, May 1991, pp. 37-38.
Monoclonal Antibody Source Book, Section 4.46, Becton Dickinson Immunocytometry Systems, 2350 Qume Drive, San Jose, CA 95131-1807.
Ferrara et al., "Evidence That Large Granular Lymphocytes of Donor Origin Mediate Acute Graft-Versus-Host Disease,"Transplantation, 47(1):50-54 (Jan. 1989).
MacDonald et al., "Prevention of Acute Lethal Graft-Versus-host Disease in F.sub.1 Hybrid Mice By Pretreatment of the Graft with Anti-NK-1.1 and Complement,"Transplantation, 54(1):147-151 (Jul. 1992).
Martin et al., "Human Marrow Transplantation: An Immunological Perspective,"Advances In Immunology, vol. 40, pp. 379-431.
E. Vivier et al., Jour. Exper. Med., 178, 2023-2033, 1993.
E.Vivier et al., Amer. Jour. Pathol., 146, 409-418, 1995.

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