Natural killer cell enhancing factor

Details Natural killer cell enhancing factor Natural killer cell enhancing factor

1991-11-04

1993-10-05

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

424 851, 514 12, 514 21, 530380, 530402, 530816, 530829, A61K 3702, C07K 1506

Patent

active

052502953

ABSTRACT:
A factor (NKEF) for use in enhancing the activity of natural killer cells both in vivo and in vitro. NKEF is a soluble red blood cell cytosol protein having a molecular mass of between about 300 and 400 kilodaltons as determined by gel filtration high pressure liquid chromatography and an apparent molecular weight of about 48 kilodaltons as determined by non-reducing SDS-PAGE.

REFERENCES:
patent: 4883661 (1989-11-01), Daly et al.
patent: 5208218 (1993-05-01), Van Snick et al.
Shau, H. and Golub, S. "Modulation of Natural Killer-Mediated Lysis by Red Blood Cells", Cellular Immunology 116, 60-72, 1988.
Karger, S., "Abstract from Seventh International Workshop on Natural Killer Cells", Jun. 4-7, 1991, Stockholm, Sweden.
Iho, S., Shau, H. and Golub, S., "Characteristics of Interleukin-6-Enhanced Lymphokine-Activated Killer Cell Function", Cellular Immunology 135, 66-77 (1991).

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