Natural inhibitor that protects against viral infections

Details Natural inhibitor that protects against viral infections Natural inhibitor that protects against viral infections

1984-05-24

1986-06-17

Wiseman, Thomas G.

Drug, bio-affecting and body treating compositions

Lymphokine

424 88, 424 93, 514 21, 435948, 435240, 435235, A61K 3900, A61K 3512, A61K 4900

Patent

active

045955883

ABSTRACT:
A treatment and prophylaxis of viral infections in mammals is provided. The method involves administering an amount of a contact-blocking viral inhibitor (CVI) sufficient to elevate the concentration of the viral inhibitor in the mammal's tissue above the naturally occurring concentration in that same tissue. Methods for purifying and concentrating CVI are presented. The cellular viral inhibitor is characterized by broad antiviral activity, potency, reversible inhibition of viral attachment, cross species activity and molecular size. Natural levels of CVI range from 6 U/0.1 ml in tears to 400 U/0.1 ml in gastric secretions, with titers between these ranges found in colostrum, milk, plasma, saliva and urine. Biochemical characterization of the CVI indicates that it resists denaturation by heat, acid and alkali, and it exhibits a molecular size on the order of 2500 daltons.

REFERENCES:
patent: 4278662 (1981-07-01), Lohmann et al.
patent: 4315914 (1982-02-01), Arakawa et al.
patent: 4341763 (1982-07-01), Zygraich
patent: 4452734 (1984-06-01), Larson et al.
patent: 4508708 (1985-04-01), Wezel
Broadly Active Inhibitor of Viruses Spontaneously Produced by Many Cell Types in Culture, Infection and Immunity, May, 1981, pp. 449-453.
Cell-Produced Viral Inhibitor: Possible Mechanism of Action and Chemical Composition, Infection and Immunity, May 1981, pp. 454-457.
The Third Annual International Congress for Interferon Research, Abstracts, Nov. 1-3, 1982.
Abstracts of the 1982 ICAAC, p. 142.

Affiliated with

Also associated with

Rating

Natural inhibitor that protects against viral infections does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Natural inhibitor that protects against viral infections, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Natural inhibitor that protects against viral infections will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2272768