Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-03-01
2008-10-28
Wehbe, Anne Marie (Department: 1633)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500, C530S324000, C435S320100, C435S325000
Reexamination Certificate
active
07442783
ABSTRACT:
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
REFERENCES:
patent: 6753314 (2004-06-01), Giot et al.
patent: WO 00/42210 (2000-07-01), None
patent: WO200175067 (2001-10-01), None
patent: WO-01/93892 (2001-12-01), None
patent: WO2003055982 (2003-07-01), None
Guo et al., Protein tolerance to random amino acid change.Proc Natl Acad Sci U S A. Jun. 22, 2004;101(25):9205-10. Epub Jun. 14, 2004.
Sryer, Biochemistry Third Edition W.H. Freeman and Company pp. 36-40.
Veronese FM. Peptide and protein PEGylation: a review of problems and solutions. Biomaterials. Mar. 2001;22(5):405-17.
Ahearn et al., “Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen,” Immunity 4:251-262 (1996).
Arnold et al., “Development of B-1 Cells: Segregation of Phosphatidyl Choline-specific B Cells to the B-1 Population Occurs After Immunoglobulin Gene Expression,” J. Exp. Med. 179:1585-1595 (1994).
Borodovsky et al., “Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family,” Chem. Biol. 9:1149-1159 (2002).
Carroll, M.C., “The role of complement and complement receptors in induction and regulation of immunity,” Ann. Rev. Immunol. 16:545-568 (1998).
Clarke, J., “B-1 Cell Development: Evidence for an Uncommityed Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation,” Exp. Med. 187:1325-1334 (1998).
Epstein et al., “The collections in innate immunity,” Immunol. 8:29-35 (1996).
Fearon et al., “The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity,” Annu. Rev. Immunol. 13:127-149 (1995).
Feeney, J., “Lack of N Regions in Fetal and Neonatal Mouse Immunoglobulin V-D-J Junctional Sequences,” Exp. Med. 172:1377-1390 (1990).
Golomb et al., “Identification and Characterization of Nonmuscle Myosin II-C, a New Member of the Myosin II Family,” J. Biol. Chem. 279:2800-2808 (2004).
Gu et al., “Sequence homologies, N sequence insertion and Jhgene utilization in VHDJHjoining: implications for the joining mechanism and the ontogenetic timing of Lyl B cell and B-CLL progenitor generation,” EMBO J 9:2133-2140 (1990).
Hardy et al., “Distinctive Development Origins and Specificities of Murine CD5+ B Cells,” Immunol. Rev. 137:91-118 (1994).
Hayakawa et al., “Immunoglobulin-bearing B cells reconstitute and maintain the murine Ly-1 B cell lineage,” Eur. J. Immunol. 16:1313-1316 (1986).
Herzenberg et al., “B-cell lineages exist in the mouse,” Immunol. Today 14:79-83, discussion 88-90 (1993).
Kantor et al., “Origin of murine B cell lineages,” Annu. Rev. Immunol. 11:501-538 (1993).
Kelley et al., “Xenopus Nonmuscle Myosin Heavy Chain Isoforms Have Different Subcellular Localizations and Enzymatic Activites,” J. Cell Biol. 134:675-687 (1996).
Molina et al., “Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2,” Proc. Natl. Acad. Sci. USA 93:3357-3361 (1996).
Muller-Eberhard, H.J., “Molecular organization and function of the complement system,” Ann. Rev. Biochem. 57:321-347 (1988).
O'Keefe et al., “Hyperresponsive B cells in CD22-deficient mice,” Science 274:798-801 (1996).
Reid et al., “Functional Activity of Natural Antibody is Altered in Cr2-Deficient Mice1,” J. Immunol. 5433-5440 (2002).
Shinkai et al., “RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement,” Cell, 68:855-867 (1992).
Shultz et al., “Mutations at the Murine Motheaten Locus Are within the Hematopoietic Cell Protein-Tyrosine Phosphatase (Hcph) Gene,” Cell 73:1445-1454 (1993).
Vorup-Jensen et al., “Structure and allosteric regulation of the αXβ2 integrin I domain,” PNAS USA 100:1873-1878 (2003).
Weiser et al., “Reperfusion Injury of Ischemic Skeletal Muscle Is Mediated by Natural Antibody and Complement,” J. Exp. Med., 183:2343-2348 (1996).
Williams et al., “Intestinal reperfusion injury is mediated by IgM and complement,” J. Appl. Physiol. 86:938-42 (1999).
Wortis, H.H., “Surface Markers, Heavy Chain Sequences and B Cell Lineages,” Int. Rev. Immunol., 8:235-246 (1992).
Zhang et al., “Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury,” PNAS USA 101:3886-91 (2004).
Database EMBL “Arabidopsis thalianaunknown protein (At3g57990) mRNA, complete cds,” XP-002343885; Database Accession No. AY122933.
Database EMBL “Aspergillus nidulansGFSC A4 chromosome I ANcontigl.116, whole genome shotgun sequence,” XP-002343886; Database Accession No. AACD01000116.
Database EMBL “Ruminococcus albusxynC gene for xylanase C, hypothetical proteins, complete and partial cds,” XP-002343887; Database Accession No. AB957589.
Austen et al., “Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM,” Surgery, 136(2):401-406.
XP002462307; “Xenopus laeviscDNA clone Image:4889191, partial cds.”; Sep. 18, 2003 (retrieved from EBI accession No. EMBL: BC057729 Database accession No. BC057729).
XP002462308; “Homo sapiensmRNA; cDNA DKFZp451J0218 (from clone DKFZp451J0218); complete cds” Jul. 10, 2002; (retrieved from EBI accession No. EMBL:AL832639).
XP002462309; “Homo sapiens, Similar to myosin, heavy polypeptide 9, non-muscle, clone Image: 5563109, mRNA partial cds”; Apr. 2, 2003; (retrieved from EBI accession No. EMBL:BC049849).
XP002462310; “Oryctolagus cuniculusmRNA for myosin heavy chain, partial cds”; May 10, 2001 (retrieved from EBI accession No. EMBL:D63694).
XP002462311; “Bos taurusnonmuscle myosin heavy chain B mRNA fragment II, partial cds”; Oct. 6, 1995; (retrieved from EBI acccession No. EMBL:U15693).
EP 05 72 3931 Search Report dated Dec. 13, 2007.
Carroll Michael C.
Hechtman Herbert B.
Moore, Jr. Francis D.
Foley & Hoag LLP
Leavitt Maria
President and Fellows of Harvard College
The Brigham and Women's Hospital, Inc.
The CBR Institute for Biomedical Research, Inc.
LandOfFree
Natural IgM antibodies and inhibitors thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Natural IgM antibodies and inhibitors thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Natural IgM antibodies and inhibitors thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4002693