Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1995-05-23
1997-10-07
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530397, 530399, 530324, 530350, 53038824, 5303892, 436510, 436549, 436548, 436814, 135 71, 135975, C07K 1600, G01N 3353
Patent
active
056749830
ABSTRACT:
The present invention relates to the purification of the human chorionic gonadotropin .beta.-core molecule which can then be used as the antigen in the preparation of antibodies to the .beta.-core molecule. The combination of the purified .beta.-core molecule and the antibodies can be used in an immunoassay kit to measure .beta.-core molecules in the presence of structurally similar molecules, i.e., hCG, LH, hCG.beta.-subunit and LH.beta.-subunit. Measurement of the .beta.-core molecule is particularly useful in testing for pregnancy and many malignancies.
REFERENCES:
patent: 4565687 (1986-01-01), Khazaeli
patent: 4804626 (1989-02-01), Bellet
patent: 4851356 (1989-07-01), Canfield
patent: 5324667 (1994-06-01), Maci
patent: 5356817 (1994-10-01), Cole
patent: 5501988 (1996-03-01), Kobayoshi et al.
Wehmann et al, J. Endocr., vol. 117, No. 1, pp. 147-152, Apr. 1988.
Akar et al, J. Clin. Endocrinol. Metab., vol. 66, No. 3, pp. 538-545, 1988.
Blithe et al, Endocrinology, vol. 122, No. 1, pp. 173-180, Jan. 1988.
Birken et al, Endocrinology, vol. 123, pp. 572-583, 1988.
Birken et al, Endocrinology, vol. 112, pp. 657-666, 1987.
Lefort et al, Endocrinology, vol. 119, pp. 924-931, 1986.
Wehmann et al, Chemical Abstracts, vol. 102, p. 72, Ref. #143383n, 1985 (Ann. Endocrinol. 1984, 45(4-5), 291-295).
Abstract Nos. B2.144.09, B2.144.10, 15th International Cancer Congress, Aug. 16-22, 1990.
Akar et al., Clin. Endo. and Metab. 66:538 (1988).
Alfthan et al., Jo. Clin. Endocrin. & Metabolism 70(3):783 (Mar. 1990).
Birken et al., Endocrinology 121(2):657 (1987).
Birken et al., Endocrinology 123(1):572 (1988).
Birken et al., J. Biol. Chem. 252:5386 (1977).
Blithe et al., Endocrinology 122(1):173 (1988).
Cole et al., Cancer Research 48:1356 (Mar. 1, 1988).
Greene et al., Methods in Enzymology XLVII:170 (1977).
Kardana et al., British Journal of Cancer58 (3) (Sep. 1988).
Kohler et al., Nature 256:495 (1975).
Krichevsky et al., Endocrinology 123 (1):584 (1988).
O'Connor et al., Cancer Research 48:1361 (Mar. 1, 1988).
Ryan et al., Recent Progress in Hormone Research 43:83 (1987).
Shome et al., J. Clin. Endo. and Metab. 36:618 (1973).
Smyth, Methods in Enzymology 11:214 (1967).
Schroeder et al., Clin. Chem. 29(4):667 (1983).
Blithe Diana L.
Nisula Bruce C.
Wehmann Robert E.
Mohamed Abdel A.
The United States of America as represented by the Department of
Tsang Cecilia J.
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